HitPredict

Interactor 1: F8VPR5 (F8VPR5)
histone acetyltransferase (EC 2.3.1.48)
Gene: Crebbp

Interactor 2: HNF1B (P27889)
Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Homeoprotein LFB3) (Transcription factor 2) (TCF-2)
Gene: HNF1B

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	15647252, 15509593
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005667 - transcription regulator complex GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2441 Mm			1 558
+	Hs
		727573 CBP_HUMAN (1-2441): 0: 1094: 94.89		HNF1B_HUMAN (1-558): 3.06e-142: 424: 96.24
+	Hs
		595946 CBP_HUMAN (1-2441): 0: 1094: 94.89		HNF1A_HUMAN (1-552): 1.95e-84: 277: 53.81
+	Hs
		620186 CBP_HUMAN (1-2441): 0: 1094: 94.89		PAX7_HUMAN (59-499): 1.41e-66: 226: 15.27
+	Hs
		641506 CBP_HUMAN (1-2441): 0: 1094: 94.89		PAX6_HUMAN (59-468): 6.44e-66: 222: 15.99
+	Hs
		727512 EP300_HUMAN (1-2426): 0: 887: 54.94		HNF1B_HUMAN (1-558): 3.06e-142: 424: 96.24
+	Mm
		799598 CBP_MOUSE (1-2441): 0: 1114: 99.55		PAX5_MOUSE (59-383): 1.59e-39: 150: 9.58
+	Hs
		988792 CBP_HUMAN (1-2441): 0: 1094: 94.89		PAX8_HUMAN (59-460): 1.28e-41: 157: 10.05
+	Hs
		595924 EP300_HUMAN (1-2426): 0: 887: 54.94		HNF1A_HUMAN (1-552): 1.95e-84: 277: 53.81
+	Hs
		620147 EP300_HUMAN (1-2426): 0: 887: 54.94		PAX7_HUMAN (59-499): 1.41e-66: 226: 15.27
+	Hs
		641388 EP300_HUMAN (1-2426): 0: 887: 54.94		PAX6_HUMAN (59-468): 6.44e-66: 222: 15.99
+	Hs
		988755 EP300_HUMAN (1-2426): 0: 887: 54.94		PAX8_HUMAN (59-460): 1.28e-41: 157: 10.05
+	Hs
		971655 EP300_HUMAN (1-2426): 0: 887: 54.94		PAX5_HUMAN (59-383): 1.28e-38: 148: 9.58
+	Mm
		70910 EP300_MOUSE (1-2426): 0: 889: 53.65		PITX2_MOUSE (166-432): 1.75e-27: 114: 15.02
+	Dm
		116025 M9PH39_DROME (514-2358): 0: 785: 36.04		Q9W1H7_DROME (220-349): 4.71e-27: 110: 23.31
+	Hs
		727560 KMT2C_HUMAN (431-1051): 2.82e-12: 75.1: 12.16		HNF1B_HUMAN (1-558): 3.06e-142: 424: 96.24
+	Hs
		595941 KMT2C_HUMAN (431-1051): 2.82e-12: 75.1: 12.16		HNF1A_HUMAN (1-552): 1.95e-84: 277: 53.81
+	Hs
		620175 KMT2C_HUMAN (431-1051): 2.82e-12: 75.1: 12.16		PAX7_HUMAN (59-499): 1.41e-66: 226: 15.27
+	Hs
		641482 KMT2C_HUMAN (431-1051): 2.82e-12: 75.1: 12.16		PAX6_HUMAN (59-468): 6.44e-66: 222: 15.99
+	Hs
		973865 KMT2C_HUMAN (431-1051): 2.82e-12: 75.1: 12.16		PAX2_HUMAN (59-383): 2.83e-44: 164: 9.14
+	Hs
		988783 KMT2C_HUMAN (431-1051): 2.82e-12: 75.1: 12.16		PAX8_HUMAN (59-460): 1.28e-41: 157: 10.05