HitPredict

Interactor 1: SCC1 (Q12158)
Sister chromatid cohesion protein 1
Gene: MCD1

Interactor 2: SMC6 (Q12749)
Structural maintenance of chromosomes protein 6 (DNA repair protein RHC18) (Rad18 homolog)
Gene: SMC6

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	33301732, 37486771
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 566 Sc			1 1114
+	Sc
		758764 SCC1_YEAST (1-566): 0: 543: 100.00		SMC2_YEAST (81-1099): 9.79e-59: 223: 12.13
+	Hs
		224468 RAD21_HUMAN (14-560): 2.56e-147: 440: 15.72		SMC5_HUMAN (35-1112): 5.81e-68: 250: 13.95
+	Hs
		224536 RAD21_HUMAN (14-560): 2.56e-147: 440: 15.72		SMC4_HUMAN (5-1100): 2.66e-60: 228: 11.78
+	Hs
		224250 RAD21_HUMAN (14-560): 2.56e-147: 440: 15.72		SMC2_HUMAN (81-1099): 1.44e-52: 203: 14.02
+	Xl
		292737 RAD21_XENLA (14-560): 5.98e-150: 446: 15.92		SMC3_XENLA (81-1098): 3.66e-50: 196: 11.57
+	Xl
		1150103 Q6DCL7_XENLA (14-560): 7.75e-150: 446: 15.61		Q8AW91_XENLA (81-1098): 1.95e-49: 193: 11.49
+	Xl
		292746 RAD21_XENLA (14-560): 5.98e-150: 446: 15.92		Q8AW91_XENLA (81-1098): 1.95e-49: 193: 11.49
+	Hs
		224554 RAD21_HUMAN (14-560): 2.56e-147: 440: 15.72		SMC3_HUMAN (81-1098): 8.48e-49: 191: 11.57
+	Mm
		1142822 RAD21_MOUSE (14-560): 1.24e-144: 433: 16.08		SMC3_MOUSE (81-1098): 6.83e-49: 191: 11.57
+	Sc
		810784 SCC1_YEAST (1-566): 0: 543: 100.00		SMC3_YEAST (247-1081): 1.13e-13: 78: 13.05
+	Mm
		57599 RD21L_MOUSE (14-561): 3.47e-143: 426: 15.49		SMC3_MOUSE (81-1098): 6.83e-49: 191: 11.57
+	Sp
		193873 RAD21_SCHPO (14-559): 7.57e-117: 361: 16.75		SMC3_SCHPO (81-1100): 3.91e-52: 202: 12.69
+	Sp
		193874 REC8_SCHPO (14-554): 5.1e-117: 359: 14.36		SMC3_SCHPO (81-1100): 3.91e-52: 202: 12.69
+	Sp
		293280 RAD21_SCHPO (14-559): 7.57e-117: 361: 16.75		SMC1_SCHPO (80-1106): 1.09e-51: 200: 12.81
+	Sp
		293281 REC8_SCHPO (14-554): 5.1e-117: 359: 14.36		SMC1_SCHPO (80-1106): 1.09e-51: 200: 12.81
+	Mm
		1207970 REC8_MOUSE (18-559): 2.03e-105: 330: 13.09		SMC3_MOUSE (81-1098): 6.83e-49: 191: 11.57
+	Dm
		332181 O96689_DROME (14-523): 2.08e-98: 316: 15.95		Q9VXE9_DROME (81-1098): 9.96e-50: 194: 11.16
+	Hs
		304460 REC8_HUMAN (18-560): 6.19e-98: 309: 14.39		SMC3_HUMAN (81-1098): 8.48e-49: 191: 11.57
+	Dm
		332177 O96689_DROME (14-523): 2.08e-98: 316: 15.95		Q9VCD8_DROME (76-969): 1.56e-22: 106: 12.01