HitPredict

Interactor 1: F8VQL0 (F8VQL0)
Hepatocyte growth factor receptor (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (Tyrosine-protein kinase Met)
Gene: Met

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	17449471, 15314156
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0019903 - protein phosphatase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1379 Mm			1 217
+	Hs
		441477 MET_HUMAN (1-1379): 0: 1336: 89.43		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		411558 MET_HUMAN (1-1379): 0: 1336: 89.43		LCK_HUMAN (3-202): 7.66e-38: 138: 28.91
+	Mm
		554964 MET_MOUSE (1-1379): 0: 1386: 99.86		FYN_MOUSE (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		441500 MET_HUMAN (1-1379): 0: 1336: 89.43		PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93
+	Hs
		441422 MET_HUMAN (1-1379): 0: 1336: 89.43		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		441462 MET_HUMAN (1-1379): 0: 1336: 89.43		ABL2_HUMAN (4-139): 9.7e-22: 94.7: 34.04
+	Hs
		441580 MET_HUMAN (1-1379): 0: 1336: 89.43		VAV3_HUMAN (3-57): 6.2e-13: 69: 38.18
+	Hs
		433219 MET_HUMAN (1-1379): 0: 1336: 89.43		YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37
+	Hs
		441406 MET_HUMAN (1-1379): 0: 1336: 89.43		FGR_HUMAN (161-215): 5.31e-12: 66.1: 33.33
+	Hs
		441403 MET_HUMAN (1-1379): 0: 1336: 89.43		HCK_HUMAN (116-215): 1.24e-11: 64.9: 19.61
+	Hs
		441472 MET_HUMAN (1-1379): 0: 1336: 89.43		VAV2_HUMAN (3-56): 6.02e-11: 63.1: 38.18
+	Hs
		441415 MET_HUMAN (1-1379): 0: 1336: 89.43		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		433529 MET_HUMAN (1-1379): 0: 1336: 89.43		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39
+	Hs
		924497 RON_HUMAN (23-1372): 0: 975: 33.57		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		872422 EPHA5_HUMAN (576-1364): 8.76e-171: 539: 18.84		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		557643 EPHA5_HUMAN (576-1364): 8.76e-171: 539: 18.84		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337359 EPHA3_HUMAN (576-1375): 4.19e-165: 522: 19.63		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		412104 EPHA5_HUMAN (576-1364): 8.76e-171: 539: 18.84		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		412036 EPHA3_HUMAN (576-1375): 4.19e-165: 522: 19.63		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		433602 EPHA3_HUMAN (576-1375): 4.19e-165: 522: 19.63		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39