HitPredict

Interactor 1: SCAP (Q12770)
Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein)
Gene: SCAP

Interactor 2: LPAR1 (Q92633)
Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2)
Gene: LPAR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.80	0.770

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	7tm_1~WD40
Common GO terms	-
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1279 Hs			1 364
+	Hs
		1016030 SCAP_HUMAN (1-1279): 0: 1140: 100.00		LPAR2_HUMAN (23-364): 1.03e-59: 197: 53.06
+	Hs
		167849 NPC1_HUMAN (7-549): 6.42e-121: 408: 20.48		MC4R_HUMAN (55-328): 2.7e-73: 232: 26.67
+	Hs
		167789 NPC1_HUMAN (7-549): 6.42e-121: 408: 20.48		S1PR4_HUMAN (1-360): 9.27e-72: 230: 30.89
+	Hs
		168040 NPC1_HUMAN (7-549): 6.42e-121: 408: 20.48		LPAR2_HUMAN (23-364): 1.03e-59: 197: 53.06
+	Hs
		373143 HMDH_HUMAN (276-489): 1.09e-53: 205: 24.19		LPAR1_HUMAN (1-364): 3.44e-73: 233: 100.00
+	Hs
		373155 HMDH_HUMAN (276-489): 1.09e-53: 205: 24.19		LPAR2_HUMAN (23-364): 1.03e-59: 197: 53.06