Interactor 1: SCAP (Q12770)
Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein)
Gene: SCAP

Interactor 2: INSI2 (Q9Y5U4)
Insulin-induced gene 2 protein (INSIG-2)
Gene: INSIG2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.867

The method score is based on:

Property Details
Experiments 32322062, 34192549, 16549805, 12242332
Identification Methods affinity chromatography technology, x-ray crystallography
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains INSIG~Sterol-sensing
Common GO terms GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0032933 - SREBP signaling pathway
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 1279
Hs

1 225
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024