HitPredict

Interactor 1: TWF1 (Q12792)
Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)
Gene: TWF1

Interactor 2: LIMA1 (Q9UHB6)
LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)
Gene: LIMA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26496610, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003785 - actin monomer binding GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0015629 - actin cytoskeleton GO:0045296 - cadherin binding and 1 others more... GO:0051015 - actin filament binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 350 Hs			1 759
+	Hs
		1152326 TWF2_HUMAN (1-344): 3.79e-159: 451: 65.41		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		1355283 COF2_HUMAN (4-138): 2.83e-38: 136: 17.53		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		618196 COF1_HUMAN (4-142): 6.84e-37: 132: 17.09		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		839867 COF2_HUMAN (4-138): 2.83e-38: 136: 17.53		CSRP3_HUMAN (254-464): 1.11e-33: 129: 15.17