HitPredict

Interactor 1: F8VWT9 (F8VWT9)
HECT domain E3 ubiquitin protein ligase 4
Gene: HECTD4

Interactor 2: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	29643511
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4284 Hs			1 147
+	Hs
		849334 UBE3C_HUMAN (3700-4276): 3.48e-146: 489: 21.38		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		919732 UBE3C_HUMAN (3700-4276): 3.48e-146: 489: 21.38		UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00
+	Hs
		895796 UBE3C_HUMAN (3700-4276): 3.48e-146: 489: 21.38		UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28
+	Hs
		125808 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20
+	Hs
		125262 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		125335 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00
+	Hs
		125300 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28
+	Hs
		849444 WWP1_HUMAN (3745-4279): 2.28e-141: 470: 17.98		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		919860 WWP1_HUMAN (3745-4279): 2.28e-141: 470: 17.98		UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00
+	Hs
		849411 ITCH_HUMAN (3745-4279): 8.27e-141: 467: 18.22		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		895910 WWP1_HUMAN (3745-4279): 2.28e-141: 470: 17.98		UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28
+	Hs
		919827 ITCH_HUMAN (3745-4279): 8.27e-141: 467: 18.22		UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00
+	Hs
		895882 ITCH_HUMAN (3745-4279): 8.27e-141: 467: 18.22		UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28
+	Hs
		125655 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73
+	Hs
		125629 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43
+	Hs
		125263 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73
+	Dm
		854579 SUDX_DROME (3752-4279): 1.9e-140: 468: 16.45		UBCD2_DROME (4-146): 1.43e-74: 223: 66.43
+	Hs
		1294835 ITCH_HUMAN (3745-4279): 8.27e-141: 467: 18.22		UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73
+	Hs
		1282329 ITCH_HUMAN (3745-4279): 8.27e-141: 467: 18.22		UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43
+	Hs
		851871 ITCH_HUMAN (3745-4279): 8.27e-141: 467: 18.22		UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73