HitPredict

Interactor 1: F8VWT9 (F8VWT9)
HECT domain E3 ubiquitin protein ligase 4
Gene: HECTD4

Interactor 2: UB2L3 (P68036)
Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3)
Gene: UBE2L3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	29643511
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4284 Hs			1 154
+	Hs
		101688 F8VWT9_HUMAN (1-4284): 0: 8395: 100.00		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		849334 UBE3C_HUMAN (3700-4276): 3.48e-146: 489: 21.38		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		919732 UBE3C_HUMAN (3700-4276): 3.48e-146: 489: 21.38		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		895796 UBE3C_HUMAN (3700-4276): 3.48e-146: 489: 21.38		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		125808 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93
+	Hs
		125262 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		125335 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Ce
		1094318 WWP1_CAEEL (3743-4279): 2.34e-154: 503: 16.91		UBC18_CAEEL (1-152): 8.21e-66: 198: 59.21
+	Hs
		125300 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		849444 WWP1_HUMAN (3745-4279): 2.28e-141: 470: 17.98		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		919860 WWP1_HUMAN (3745-4279): 2.28e-141: 470: 17.98		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		125629 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2E3_HUMAN (2-149): 2.39e-68: 207: 34.90
+	Hs
		125655 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2E2_HUMAN (2-149): 1.55e-68: 207: 34.90
+	Hs
		895910 WWP1_HUMAN (3745-4279): 2.28e-141: 470: 17.98		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		932518 UBE3C_HUMAN (3700-4276): 3.48e-146: 489: 21.38		UB2L3_HUMAN (1-154): 1.26e-64: 196: 100.00
+	Hs
		125263 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2E1_HUMAN (2-149): 6.55e-67: 203: 34.90
+	Hs
		125359 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2L3_HUMAN (1-154): 1.26e-64: 196: 100.00
+	Hs
		932530 HECD2_HUMAN (3707-4279): 3.93e-147: 481: 15.76		UB2L3_HUMAN (1-154): 1.26e-64: 196: 100.00
+	Mm
		932608 WWP2_MOUSE (3618-4279): 1.23e-144: 477: 16.71		UB2L3_MOUSE (1-154): 1.26e-64: 196: 100.00
+	Hs
		125000 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		UB2L6_HUMAN (1-152): 4e-53: 166: 55.26