HitPredict

Interactor 1: F8W9P4 (F8W9P4)
phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153)
Gene: PIK3CD

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	26496610
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~PI3_PI4_kinase, PI3_PI4_kinase~SH2, PI3K_C2~PI3K_P85_iSH2, PI3K_C2~SH2, PI3K_P85_iSH2~PI3K_p85B, PI3K_P85_iSH2~PI3Ka, PI3Ka~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005942 - phosphatidylinositol 3-kinase complex GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1068 Hs			1 724
+	Hs
		126190 PK3CD_HUMAN (1-1068): 0: 1163: 87.22		P85A_HUMAN (1-724): 0: 596: 100.00
+	Mm
		193568 PK3CD_MOUSE (1-1068): 0: 1153: 82.41		P85A_MOUSE (1-724): 0: 592: 95.99
+	Hs
		126184 PK3CD_HUMAN (1-1068): 0: 1163: 87.22		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Mm
		643106 PK3CB_MOUSE (1-1067): 0: 1038: 50.85		P85A_MOUSE (1-724): 0: 592: 95.99
+	Hs
		655252 PK3CB_HUMAN (1-1067): 0: 1014: 51.39		P85A_HUMAN (1-724): 0: 596: 100.00
+	Mm
		643067 PK3CA_MOUSE (1-1065): 0: 976: 37.95		P85A_MOUSE (1-724): 0: 592: 95.99
+	Hs
		655251 PK3CA_HUMAN (1-1065): 0: 971: 37.77		P85A_HUMAN (1-724): 0: 596: 100.00
+	Bt
		619995 PK3CA_BOVIN (1-1065): 0: 973: 37.86		P85A_BOVIN (1-724): 0: 585: 96.82
+	Hs
		129231 PK3CB_HUMAN (1-1067): 0: 1014: 51.39		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		126198 PK3CD_HUMAN (1-1068): 0: 1163: 87.22		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Bt
		619993 PK3CA_BOVIN (1-1065): 0: 973: 37.86		P85B_BOVIN (4-719): 3.55e-163: 489: 56.91
+	Hs
		129230 PK3CA_HUMAN (1-1065): 0: 971: 37.77		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		655269 PK3CG_HUMAN (1-1062): 0: 844: 27.72		P85A_HUMAN (1-724): 0: 596: 100.00
+	Mm
		1145021 PK3CB_MOUSE (1-1067): 0: 1038: 50.85		P55G_MOUSE (271-723): 9.81e-103: 324: 70.99
+	Hs
		787386 PK3CB_HUMAN (1-1067): 0: 1014: 51.39		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		787279 PK3CA_HUMAN (1-1065): 0: 971: 37.77		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Mm
		787350 PK3CA_MOUSE (1-1065): 0: 976: 37.95		P55G_MOUSE (271-723): 9.81e-103: 324: 70.99
+	Dm
		113886 P91634_DROME (9-1068): 0: 921: 37.03		M9PAY7_DROME (322-428): 1.98e-13: 71.4: 27.78
+	Dm
		186278 P91634_DROME (9-1068): 0: 921: 37.03		O18683_DROME (319-465): 9.73e-10: 63.5: 20.95
+	Ce
		106194 AGE1_CAEEL (14-1065): 0: 778: 24.89		G5EDP9_CAEEL (607-722): 6.5e-17: 86.4: 27.97