HitPredict

Interactor 1: M3K12 (Q12852)
Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase)
Gene: MAP3K12

Interactor 2: T22D1 (Q15714)
TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein)
Gene: TSC22D1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	16169070
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 859 Hs			1 1073
+	Hs
		337335 ABL1_HUMAN (15-858): 9.77e-130: 418: 19.30		MUC1_HUMAN (241-1069): 1.4e-45: 181: 9.20
+	Hs
		411582 LCK_HUMAN (9-377): 7.81e-129: 397: 26.04		MUC1_HUMAN (241-1069): 1.4e-45: 181: 9.20
+	Hs
		433560 LYN_HUMAN (9-365): 5.62e-128: 395: 26.42		MUC1_HUMAN (241-1069): 1.4e-45: 181: 9.20
+	Hs
		522749 SRC_HUMAN (12-377): 2.24e-127: 394: 23.75		MUC1_HUMAN (241-1069): 1.4e-45: 181: 9.20
+	Mm
		101424 LYN_MOUSE (9-365): 6.18e-128: 395: 26.69		F8VPR5_MOUSE (7-1050): 1.31e-44: 179: 9.92
+	Hs
		199532 M3K13_HUMAN (21-858): 6.44e-145: 454: 51.26		SON_HUMAN (486-849): 3.79e-10: 66.5: 16.71
+	Hs
		297808 LYN_HUMAN (9-365): 5.62e-128: 395: 26.42		K0754_HUMAN (4-364): 1.83e-23: 110: 12.53
+	Hs
		1025245 AAPK1_HUMAN (100-634): 7.83e-128: 396: 18.66		T22D4_HUMAN (817-1056): 3.61e-23: 105: 34.15
+	Hs
		1183084 MARK2_HUMAN (70-778): 2.53e-139: 434: 16.71		CBP_HUMAN (362-900): 7.28e-09: 62.4: 12.04
+	Hs
		152571 ABL1_HUMAN (15-858): 9.77e-130: 418: 19.30		KMT2D_HUMAN (25-798): 6.74e-09: 62.7: 13.60
+	Dm
		1370316 Q9VW24_DROME (1-855): 6.2e-127: 407: 34.90		Q9VLS7_DROME (1-689): 2.91e-10: 67: 9.43
+	Hs
		152597 AKT1_HUMAN (19-422): 1.15e-130: 401: 18.65		KMT2D_HUMAN (25-798): 6.74e-09: 62.7: 13.60
+	Hs
		681959 AKT1_HUMAN (19-422): 1.15e-130: 401: 18.65		CBP_HUMAN (362-900): 7.28e-09: 62.4: 12.04
+	Hs
		203198 LCK_HUMAN (9-377): 7.81e-129: 397: 26.04		SYNJ1_HUMAN (359-780): 1.74e-09: 64.5: 13.12
+	Hs
		433930 LYN_HUMAN (9-365): 5.62e-128: 395: 26.42		CBP_HUMAN (362-900): 7.28e-09: 62.4: 12.04
+	Hs
		523092 SRC_HUMAN (12-377): 2.24e-127: 394: 23.75		CBP_HUMAN (362-900): 7.28e-09: 62.4: 12.04
+	Hs
		442866 HCK_HUMAN (9-365): 6.67e-125: 388: 26.15		CBP_HUMAN (362-900): 7.28e-09: 62.4: 12.04