HitPredict

Interactor 1: MERTK (Q12866)
Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)
Gene: MERTK

Interactor 2: HYOU1 (Q9Y4L1)
Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)
Gene: HYOU1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 999 Hs			1 999
+	Hs
		665690 EPHB2_HUMAN (28-991): 0: 653: 18.14		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		665546 EPHA8_HUMAN (47-973): 0: 607: 18.38		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		1072565 EPHA7_HUMAN (47-977): 0: 647: 17.92		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		665505 EPHA8_HUMAN (47-973): 0: 607: 18.38		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320817 EPHA8_HUMAN (47-973): 0: 607: 18.38		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		1128944 EPHAA_HUMAN (46-977): 1.83e-160: 500: 16.41		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		972379 TIE2_HUMAN (87-859): 1.29e-155: 491: 22.06		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		435811 IGF1R_HUMAN (318-859): 5.21e-138: 449: 28.34		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		411535 INSR_HUMAN (326-864): 3.29e-136: 445: 29.84		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		320868 EPHAA_HUMAN (46-977): 1.83e-160: 500: 16.41		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		411458 INSR_HUMAN (326-864): 3.29e-136: 445: 29.84		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320797 IGF1R_HUMAN (318-859): 5.21e-138: 449: 28.34		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		320795 INSR_HUMAN (326-864): 3.29e-136: 445: 29.84		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		441591 MET_HUMAN (568-901): 1.17e-67: 249: 40.88		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Mm
		555006 MET_MOUSE (568-898): 5.03e-68: 251: 41.84		HS105_MOUSE (33-970): 0: 818: 24.84
+	Hs
		441447 MET_HUMAN (568-901): 1.17e-67: 249: 40.88		HSP74_HUMAN (33-964): 0: 785: 25.64
+	Hs
		503499 EPHB2_HUMAN (28-991): 0: 653: 18.14		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		435511 IGF1R_HUMAN (318-859): 5.21e-138: 449: 28.34		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Rn
		544811 INSR_RAT (326-864): 2.31e-136: 445: 29.48		HSP7C_RAT (682-815): 1.96e-30: 130: 16.42
+	Hs
		503944 RON_HUMAN (535-861): 1.17e-59: 225: 37.95		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42