HitPredict

Interactor 1: CHD3 (Q12873)
Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.12) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH)
Gene: CHD3

Interactor 2: MB3L1 (Q8WWY6)
Methyl-CpG-binding domain protein 3-like 1 (MBD3-like protein 1)
Gene: MBD3L1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26186194, 28514442, 15456747, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2000 Hs			1 194
+	Hs
		328540 CHD3_HUMAN (1-2000): 0: 1917: 100.00		MBD3_HUMAN (1-193): 3.4e-102: 297: 44.56
+	Hs
		1018729 CHD3_HUMAN (1-2000): 0: 1917: 100.00		MBD2_HUMAN (1-182): 5.61e-85: 258: 41.76
+	Hs
		1018596 CHD3_HUMAN (1-2000): 0: 1917: 100.00		MB3L2_HUMAN (26-187): 5.81e-61: 190: 45.73
+	Hs
		328615 CHD5_HUMAN (43-1961): 0: 1610: 66.45		MBD3_HUMAN (1-193): 3.4e-102: 297: 44.56
+	Hs
		1255034 CHD5_HUMAN (43-1961): 0: 1610: 66.45		MB3L1_HUMAN (1-194): 1.26e-98: 285: 100.00
+	Hs
		1255049 CHD5_HUMAN (43-1961): 0: 1610: 66.45		MBD2_HUMAN (1-182): 5.61e-85: 258: 41.76
+	Hs
		328558 CHD4_HUMAN (132-1922): 0: 1552: 69.84		MBD3_HUMAN (1-193): 3.4e-102: 297: 44.56
+	Mm
		1161084 CHD4_MOUSE (6-1911): 0: 1551: 66.77		MBD3_MOUSE (1-193): 1.26e-101: 296: 43.52
+	Mm
		1125399 Q5DTP7_MOUSE (6-1911): 0: 1546: 66.41		MBD3_MOUSE (1-193): 1.26e-101: 296: 43.52
+	Hs
		1059762 CHD4_HUMAN (132-1922): 0: 1552: 69.84		MB3L1_HUMAN (1-194): 1.26e-98: 285: 100.00
+	Hs
		1059915 CHD4_HUMAN (132-1922): 0: 1552: 69.84		MBD2_HUMAN (1-182): 5.61e-85: 258: 41.76
+	Hs
		1246251 CHD5_HUMAN (43-1961): 0: 1610: 66.45		MB3L2_HUMAN (26-187): 5.81e-61: 190: 45.73
+	Hs
		1059746 CHD4_HUMAN (132-1922): 0: 1552: 69.84		MB3L2_HUMAN (26-187): 5.81e-61: 190: 45.73
+	Dm
		332827 CHDM_DROME (78-1944): 0: 1408: 52.01		Q9V424_DROME (19-172): 3.98e-61: 191: 28.66
+	Dm
		332848 CHDM_DROME (78-1944): 0: 1408: 52.01		Q9VHB7_DROME (19-172): 3.67e-59: 190: 28.66
+	Hs
		229269 SMCA5_HUMAN (584-1612): 0: 778: 27.17		MBD3_HUMAN (1-193): 3.4e-102: 297: 44.56
+	Hs
		328499 SMCA1_HUMAN (622-1597): 0: 776: 28.08		MBD3_HUMAN (1-193): 3.4e-102: 297: 44.56
+	Hs
		229512 SMCA5_HUMAN (584-1612): 0: 778: 27.17		MBD2_HUMAN (1-182): 5.61e-85: 258: 41.76
+	Hs
		658746 SMCA1_HUMAN (622-1597): 0: 776: 28.08		MBD2_HUMAN (1-182): 5.61e-85: 258: 41.76
+	Hs
		328513 SMCA2_HUMAN (73-1644): 0: 718: 20.07		MBD3_HUMAN (1-193): 3.4e-102: 297: 44.56