HitPredict

Interactor 1: CHD3 (Q12873)
Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.12) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH)
Gene: CHD3

Interactor 2: KLF12 (Q9Y4X4)
Krueppel-like factor 12 (Transcriptional repressor AP-2rep)
Gene: KLF12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2000 Hs			1 402
+	Hs
		884144 CHD3_HUMAN (1-2000): 0: 1917: 100.00		KLF3_HUMAN (20-402): 3.5e-72: 231: 38.48
+	Hs
		563706 CHD3_HUMAN (1-2000): 0: 1917: 100.00		ZKSC1_HUMAN (32-375): 5.9e-53: 186: 15.79
+	Hs
		435074 CHD3_HUMAN (1-2000): 0: 1917: 100.00		SP1_HUMAN (308-399): 8.44e-25: 108: 54.35
+	Hs
		1018504 CHD3_HUMAN (1-2000): 0: 1917: 100.00		ZKSC8_HUMAN (61-221): 2.15e-11: 67.5: 9.20
+	Hs
		563711 CHD4_HUMAN (132-1922): 0: 1552: 69.84		ZKSC1_HUMAN (32-375): 5.9e-53: 186: 15.79
+	Mm
		1141389 CHD4_MOUSE (6-1911): 0: 1551: 66.77		KLF4_MOUSE (298-399): 8.4e-38: 144: 66.67
+	Hs
		1059638 CHD4_HUMAN (132-1922): 0: 1552: 69.84		ZKSC8_HUMAN (61-221): 2.15e-11: 67.5: 9.20
+	Hs
		1254448 CHD6_HUMAN (218-1804): 0: 861: 24.77		KLF12_HUMAN (1-402): 3.29e-117: 348: 100.00
+	Hs
		1350247 CHD7_HUMAN (503-1804): 0: 837: 28.86		KLF12_HUMAN (1-402): 3.29e-117: 348: 100.00
+	Hs
		317017 CHD7_HUMAN (503-1804): 0: 837: 28.86		KLF8_HUMAN (38-399): 4.58e-105: 316: 44.11
+	Hs
		884208 CHD6_HUMAN (218-1804): 0: 861: 24.77		KLF3_HUMAN (20-402): 3.5e-72: 231: 38.48
+	Hs
		229347 SMCA5_HUMAN (584-1612): 0: 778: 27.17		KLF3_HUMAN (20-402): 3.5e-72: 231: 38.48
+	Hs
		1315379 CHD7_HUMAN (503-1804): 0: 837: 28.86		KLF16_HUMAN (317-399): 2.04e-29: 116: 65.06
+	Hs
		846731 SMCA2_HUMAN (73-1644): 0: 718: 20.07		KLF3_HUMAN (20-402): 3.5e-72: 231: 38.48
+	Hs
		846771 SMCA2_HUMAN (73-1644): 0: 718: 20.07		KLF5_HUMAN (296-399): 7.13e-45: 162: 76.92
+	Hs
		204131 SMCA2_HUMAN (73-1644): 0: 718: 20.07		KLF4_HUMAN (298-399): 1.24e-37: 144: 66.67
+	Hs
		658671 SMCA1_HUMAN (622-1597): 0: 776: 28.08		KLF9_HUMAN (336-399): 6.93e-09: 58.2: 45.46