HitPredict

Interactor 1: NMDE1 (Q12879)
Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A)
Gene: GRIN2A

Interactor 2: DLG1 (Q12959)
Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)
Gene: DLG1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.625

Property	Details
Experiments	12933808, 8601796
Identification Methods	pull down, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0007268 - chemical synaptic transmission GO:0097060 - synaptic membrane GO:0098839 - postsynaptic density membrane and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1464 Hs			1 904
+	Rn
		962655 NMDE1_RAT (1-1464): 0: 1778: 95.22		DLG1_RAT (1-904): 0: 701: 92.54
+	Rn
		962656 NMDE1_RAT (1-1464): 0: 1778: 95.22		DLG3_RAT (99-904): 0: 590: 64.57
+	Hs
		1018905 NMDE1_HUMAN (1-1464): 0: 1763: 100.00		DLG3_HUMAN (139-904): 0: 585: 66.28
+	Hs
		1021485 NMDE2_HUMAN (4-1464): 0: 1550: 52.95		DLG1_HUMAN (1-904): 0: 725: 100.00
+	Mm
		963751 NMDE2_MOUSE (4-1464): 0: 1534: 52.82		DLG1_MOUSE (1-904): 0: 720: 95.47
+	Rn
		962663 NMDE2_RAT (4-1464): 0: 1537: 52.82		DLG1_RAT (1-904): 0: 701: 92.54
+	Hs
		1028145 NMDE2_HUMAN (4-1464): 0: 1550: 52.95		DLG3_HUMAN (139-904): 0: 585: 66.28
+	Rn
		962664 NMDE2_RAT (4-1464): 0: 1537: 52.82		DLG3_RAT (99-904): 0: 590: 64.57
+	Mm
		936175 NMDE2_MOUSE (4-1464): 0: 1534: 52.82		DLG3_MOUSE (99-904): 0: 589: 64.69
+	Mm
		723533 NMDE1_MOUSE (1-1464): 0: 1787: 95.29		DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07
+	Rn
		677780 NMDE1_RAT (1-1464): 0: 1778: 95.22		DLG4_RAT (86-493): 2.93e-24: 111: 15.40
+	Rn
		962657 NMDE1_RAT (1-1464): 0: 1778: 95.22		DLG2_RAT (393-627): 2.93e-21: 101: 24.48
+	Hs
		942334 NMDE1_HUMAN (1-1464): 0: 1763: 100.00		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64
+	Hs
		1018896 NMDE1_HUMAN (1-1464): 0: 1763: 100.00		DLG2_HUMAN (393-627): 7.26e-21: 100: 24.48
+	Hs
		942337 NMDE2_HUMAN (4-1464): 0: 1550: 52.95		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64
+	Hs
		1028139 NMDE2_HUMAN (4-1464): 0: 1550: 52.95		SCRIB_HUMAN (217-396): 1.59e-23: 109: 41.49
+	Hs
		1028140 NMDE2_HUMAN (4-1464): 0: 1550: 52.95		DLG2_HUMAN (393-627): 7.26e-21: 100: 24.48
+	Rn
		677781 NMDE2_RAT (4-1464): 0: 1537: 52.82		DLG4_RAT (86-493): 2.93e-24: 111: 15.40
+	Mm
		963732 NMDE2_MOUSE (4-1464): 0: 1534: 52.82		DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07
+	Rn
		962666 NMDE2_RAT (4-1464): 0: 1537: 52.82		DLG2_RAT (393-627): 2.93e-21: 101: 24.48