HitPredict

Interactor 1: TP53B (Q12888)
TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Gene: TP53BP1

Interactor 2: UBP28 (Q96RU2)
Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28)
Gene: USP28

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.706

Property	Details
Experiments	27546791, 29656893, 33606978, 16901786, 19615732
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000077 - DNA damage checkpoint signaling GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0016604 - nuclear body
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1972 Hs			1 1077
+	Hs
		1056946 MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33		UBP28_HUMAN (1-1077): 0: 1069: 100.00
+	Hs
		1018997 TP53B_HUMAN (1-1972): 0: 766: 100.00		UBP34_HUMAN (151-417): 5.88e-65: 243: 24.64
+	Mm
		541463 MAP1B_MOUSE (66-1605): 2.35e-49: 196: 8.75		UBP48_MOUSE (145-399): 4.73e-71: 259: 26.52
+	Hs
		1056916 MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33		UBP13_HUMAN (28-649): 3.31e-72: 259: 12.85
+	Hs
		800642 SRRM2_HUMAN (18-1418): 1.61e-14: 82.2: 9.78		UBP5_HUMAN (28-649): 4.98e-77: 273: 12.71
+	Dm
		54344 A1Z9J3_DROME (566-1248): 2.07e-18: 95.2: 13.41		UBP36_DROME (1-544): 1.84e-68: 251: 14.97
+	Dm
		1366516 Q9VGW4_DROME (46-1197): 2.54e-13: 78.2: 12.48		UBP36_DROME (1-544): 1.84e-68: 251: 14.97
+	Hs
		1056938 MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33		UBP47_HUMAN (156-403): 7.25e-49: 191: 19.85
+	Hs
		965156 ANK2_HUMAN (3-1685): 1.72e-50: 200: 9.45		UBP42_HUMAN (481-651): 4.17e-10: 66.5: 19.77
+	Hs
		1264777 TITIN_HUMAN (6-1527): 2.77e-31: 137: 9.47		UBP7_HUMAN (547-839): 8.01e-23: 107: 20.13
+	Hs
		1056917 MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33		UBP7_HUMAN (547-839): 8.01e-23: 107: 20.13
+	Hs
		1273971 SRRM2_HUMAN (18-1418): 1.61e-14: 82.2: 9.78		UBP7_HUMAN (547-839): 8.01e-23: 107: 20.13
+	Hs
		1334352 SRRM2_HUMAN (18-1418): 1.61e-14: 82.2: 9.78		UBP42_HUMAN (481-651): 4.17e-10: 66.5: 19.77