HitPredict

Interactor 1: KLRB1 (Q12918)
Killer cell lectin-like receptor subfamily B member 1 (C-type lectin domain family 5 member B) (HNKR-P1a) (NKR-P1A) (Natural killer cell surface protein P1A) (CD antigen CD161)
Gene: KLRB1

Interactor 2: CLC2D (Q9UHP7)
C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin)
Gene: CLEC2D

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21572041
Identification Methods	surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Lectin_C~Lectin_C
Common GO terms	GO:0004888 - transmembrane signaling receptor activity GO:0005886 - plasma membrane GO:0007166 - cell surface receptor signaling pathway GO:0009986 - cell surface GO:0030246 - carbohydrate binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 225 Hs			1 191
+	Hs
		530384 CSPG2_HUMAN (3-223): 4.03e-59: 202: 13.87		PGCB_HUMAN (6-190): 1.2e-44: 159: 13.30
+	Hs
		1129046 COL12_HUMAN (82-217): 1.35e-43: 157: 22.92		CLC2D_HUMAN (1-191): 2.05e-63: 196: 100.00
+	Mm
		653899 KLRBC_MOUSE (1-219): 2.26e-57: 182: 47.03		CLC2I_MOUSE (41-190): 7.37e-45: 149: 45.70
+	Hs
		1329767 CLC4M_HUMAN (70-220): 9.38e-52: 173: 19.87		CLC4M_HUMAN (72-188): 4.01e-45: 155: 28.68
+	Hs
		1329768 CLC4M_HUMAN (70-220): 9.38e-52: 173: 19.87		CD209_HUMAN (72-188): 5.05e-43: 149: 30.23
+	Hs
		1342238 CD209_HUMAN (69-214): 6.41e-48: 164: 19.87		CD209_HUMAN (72-188): 5.05e-43: 149: 30.23
+	Hs
		426840 CL17A_HUMAN (93-216): 2.54e-44: 154: 22.05		ASGR2_HUMAN (23-189): 1.21e-46: 156: 21.08
+	Hs
		426865 CLC7A_HUMAN (3-216): 8.08e-46: 154: 23.01		ASGR2_HUMAN (23-189): 1.21e-46: 156: 21.08
+	Hs
		59764 COL12_HUMAN (82-217): 1.35e-43: 157: 22.92		KLRG2_HUMAN (33-186): 7.9e-44: 152: 28.93
+	Hs
		1170205 CL17A_HUMAN (93-216): 2.54e-44: 154: 22.05		CL17A_HUMAN (72-187): 1.27e-40: 142: 31.20
+	Dr
		60054 A4JYN2_DANRE (22-223): 1.49e-41: 152: 11.11		A4JYN2_DANRE (52-187): 1.19e-36: 136: 18.24
+	Hs
		644535 NKG2C_HUMAN (2-214): 3.32e-46: 154: 21.13		NKG2A_HUMAN (23-188): 8.34e-38: 132: 19.77
+	Hs
		644632 CLC7A_HUMAN (3-216): 8.08e-46: 154: 23.01		NKG2A_HUMAN (23-188): 8.34e-38: 132: 19.77
+	Hs
		644622 KLRG1_HUMAN (1-212): 3.84e-46: 153: 23.59		NKG2A_HUMAN (23-188): 8.34e-38: 132: 19.77
+	Hs
		1129021 COL12_HUMAN (82-217): 1.35e-43: 157: 22.92		CL12A_HUMAN (48-191): 1.63e-34: 124: 23.33
+	Hs
		1315571 CLC7A_HUMAN (3-216): 8.08e-46: 154: 23.01		CLC7A_HUMAN (20-187): 5.72e-36: 127: 20.00
+	Hs
		644672 NKG2C_HUMAN (2-214): 3.32e-46: 154: 21.13		KLRD1_HUMAN (33-189): 2.76e-34: 121: 24.72
+	Hs
		1129031 COL12_HUMAN (82-217): 1.35e-43: 157: 22.92		CLC4F_HUMAN (77-152): 6.03e-26: 105: 33.77