HitPredict

Interactor 1: EPS8 (Q12929)
Epidermal growth factor receptor kinase substrate 8
Gene: EPS8

Interactor 2: ABI1 (Q8IZP0)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.857

Property	Details
Experiments	9010225, 14565974, 11099046
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH3_1~SH3_1
Common GO terms	GO:0014069 - postsynaptic density GO:0030426 - growth cone GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 508
+	Mm
		995948 EPS8_MOUSE (1-822): 0: 956: 89.05		ABI1_MOUSE (1-508): 1.42e-122: 369: 91.93
+	Mm
		913884 EPS8_MOUSE (1-822): 0: 956: 89.05		ABI2_MOUSE (1-508): 4.85e-88: 279: 61.18
+	Hs
		1224645 ES8L2_HUMAN (7-811): 0: 769: 40.67		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		1224620 ES8L1_HUMAN (29-805): 0: 717: 35.60		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		1020402 EPS8_HUMAN (1-822): 0: 994: 100.00		ITSN2_HUMAN (44-508): 6.18e-18: 89.8: 11.98
+	Hs
		1255835 ES8L1_HUMAN (29-805): 0: 717: 35.60		ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84
+	Hs
		1224619 ES8L3_HUMAN (37-672): 3.77e-172: 511: 28.07		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Ce
		105690 G5ED33_CAEEL (62-813): 0: 613: 24.94		Q10929_CAEEL (3-503): 2.93e-67: 225: 28.94
+	Hs
		802871 CRKL_HUMAN (487-662): 3.07e-33: 132: 20.79		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		433413 YES_HUMAN (448-612): 4.43e-29: 124: 16.00		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		412258 FYN_HUMAN (454-613): 1.08e-27: 120: 16.57		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		1270628 STAM1_HUMAN (458-779): 1.1e-47: 180: 15.29		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Hs
		802918 CRKL_HUMAN (487-662): 3.07e-33: 132: 20.79		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Hs
		433350 YES_HUMAN (448-612): 4.43e-29: 124: 16.00		SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72
+	Hs
		207845 PPIP1_HUMAN (423-588): 1.18e-29: 124: 18.56		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Hs
		412404 FYN_HUMAN (454-613): 1.08e-27: 120: 16.57		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Hs
		433354 YES_HUMAN (448-612): 4.43e-29: 124: 16.00		LASP1_HUMAN (285-503): 9.91e-33: 127: 19.28
+	Mm
		763381 FYN_MOUSE (454-613): 1.99e-27: 119: 16.57		HCLS1_MOUSE (266-503): 2.48e-29: 122: 20.07
+	Hs
		166024 FYN_HUMAN (454-613): 1.08e-27: 120: 16.57		SYNJ2_HUMAN (39-458): 2.1e-26: 115: 13.88
+	Hs
		412426 FYN_HUMAN (454-613): 1.08e-27: 120: 16.57		CD2AP_HUMAN (451-508): 2.26e-14: 77.9: 40.68