HitPredict

Interactor 1: EPS8 (Q12929)
Epidermal growth factor receptor kinase substrate 8
Gene: EPS8

Interactor 2: BI2L1 (Q9UHR4)
BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)
Gene: BAIAP2L1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	22921828, 21098279
Identification Methods	pull down, affinity chromatography technology, nuclear magnetic resonance, isothermal titration calorimetry, peptide array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005886 - plasma membrane GO:0051017 - actin filament bundle assembly GO:0051764 - actin crosslink formation GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 822 Hs			1 511
+	Hs
		1020413 EPS8_HUMAN (1-822): 0: 994: 100.00		BAIP2_HUMAN (6-505): 1.42e-118: 361: 39.55
+	Mm
		995947 EPS8_MOUSE (1-822): 0: 956: 89.05		BAIP2_MOUSE (6-510): 1.14e-123: 373: 39.30
+	Hs
		1255836 ES8L1_HUMAN (29-805): 0: 717: 35.60		BAIP2_HUMAN (6-505): 1.42e-118: 361: 39.55
+	Hs
		1020402 EPS8_HUMAN (1-822): 0: 994: 100.00		ITSN2_HUMAN (225-399): 4.87e-10: 64.6: 14.29
+	Rn
		88583 D3ZDV2_RAT (650-805): 8.34e-41: 162: 40.76		BAIP2_RAT (6-510): 1.36e-124: 376: 39.30
+	Hs
		557833 NCK1_HUMAN (536-621): 1.03e-18: 90.8: 30.23		BAIP2_HUMAN (6-505): 1.42e-118: 361: 39.55
+	Hs
		209189 NCK2_HUMAN (535-612): 1.02e-12: 72.7: 24.69		BAIP2_HUMAN (6-505): 1.42e-118: 361: 39.55
+	Mm
		1142985 PACN1_MOUSE (435-586): 2.47e-27: 118: 17.53		PACN1_MOUSE (7-400): 5.06e-87: 276: 13.33
+	Hs
		207753 PPIP1_HUMAN (423-588): 1.18e-29: 124: 18.56		PPIP1_HUMAN (10-400): 3.63e-66: 221: 14.61