HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 25996949, 14743216, 29748372, 32296183, 33961781, 21903422, 10544141, 15383523, 9500555, 14557256, 9718306, 19287455, 8069916, 28514442, 8702708, 37081115, 20385093, 11181075, 15323523, 31515488 and 1 others

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Identification Methods affinity chromatography technology, two hybrid, fluorescent resonance energy transfer, pull down, tandem affinity purification, anti tag coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains TRAF_BIRC3_bd~TRAF_BIRC3_bd
Common GO terms GO:0005164 - tumor necrosis factor receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0009898 - cytoplasmic side of plasma membrane
and 6 others

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Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 501
Hs

1 416
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Last updated: 15 Jul 2024