HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: UBP4 (Q13107)
Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog)
Gene: USP4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	22029577
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Hs			1 963
+	Hs
		1024451 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP4_HUMAN (1-963): 0: 908: 100.00
+	Mm
		715072 TRAF6_MOUSE (2-498): 2.51e-110: 339: 27.87		UBP4_MOUSE (1-963): 0: 895: 90.76
+	Hs
		584941 RO52_HUMAN (28-368): 2.44e-56: 196: 12.68		UBP4_HUMAN (1-963): 0: 908: 100.00
+	Hs
		1377846 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP15_HUMAN (1-924): 0: 749: 58.17
+	Rn
		88506 D3Z9G0_RAT (9-501): 8.62e-114: 349: 31.57		UBP11_RAT (6-963): 0: 705: 43.44
+	Hs
		1313391 TRAF4_HUMAN (17-498): 1.52e-94: 296: 29.12		UBP15_HUMAN (1-924): 0: 749: 58.17
+	Hs
		1020995 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		UBP20_HUMAN (203-962): 3.45e-110: 363: 17.72
+	Hs
		301460 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP19_HUMAN (183-937): 6.87e-148: 474: 30.87
+	Hs
		1257048 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP33_HUMAN (203-962): 7.87e-114: 374: 18.72
+	Hs
		1377300 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP20_HUMAN (203-962): 3.45e-110: 363: 17.72
+	Hs
		271081 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		UBP2_HUMAN (604-928): 8.22e-65: 231: 23.55
+	Hs
		301359 RO52_HUMAN (28-368): 2.44e-56: 196: 12.68		UBP19_HUMAN (183-937): 6.87e-148: 474: 30.87
+	Hs
		1020743 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		U17L2_HUMAN (737-935): 1.07e-56: 206: 26.50
+	Hs
		271228 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP2_HUMAN (604-928): 8.22e-65: 231: 23.55
+	Hs
		1356323 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP21_HUMAN (651-928): 3.71e-63: 226: 25.00
+	Hs
		1024693 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		U17L2_HUMAN (737-935): 1.07e-56: 206: 26.50
+	Hs
		1020756 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		UBP31_HUMAN (484-741): 2.35e-14: 80: 8.45
+	Hs
		271082 TRAF1_HUMAN (130-499): 1.15e-88: 279: 37.44		UBP2_HUMAN (604-928): 8.22e-65: 231: 23.55
+	Hs
		271032 RO52_HUMAN (28-368): 2.44e-56: 196: 12.68		UBP2_HUMAN (604-928): 8.22e-65: 231: 23.55
+	Hs
		1377879 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP3_HUMAN (303-482): 1e-15: 83.2: 29.74