HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.995

The method score is based on:

Property Details
Experiments 25716317, 28514442, 27534557, 30561431, 33961781, 8943045, 10753917, 35089437, 37081115, 20562859, 16282325, 19815541, 21903422, 20348096, 19584093, 20184394, 11181075, 8548810, 16891304, 23007157 and 18 others

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Identification Methods affinity chromatography technology, two hybrid, pull down, enzymatic study, anti tag coimmunoprecipitation, virotrap, two hybrid prey pooling approach, two hybrid array, validated two hybrid, two hybrid pooling approach and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains BIR~TRAF_BIRC3_bd
Common GO terms GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0009898 - cytoplasmic side of plasma membrane
and 6 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 501
Hs

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Last updated: 15 Jul 2024