HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.768

The method score is based on:

Property Details
Experiments 25882049, 27768232, 8612133, 9020361, 35165513, 21282461, 24434549, 25416956, 25716317, 29352166, 30561431, 32296183, 31502302, 8702708, 11479302, 16603398, 21810480, 19815541, 20577214, 11181075 and 5 others

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Identification Methods affinity chromatography technology, two hybrid, enzymatic study, pull down, anti tag coimmunoprecipitation, validated two hybrid, virotrap, anti bait coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005829 - cytosol
GO:0030163 - protein catabolic process
GO:0031625 - ubiquitin protein ligase binding
GO:0033209 - tumor necrosis factor-mediated signaling pathway
GO:0035591 - signaling adaptor activity
and 6 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024