HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: Q7KZS0 (Q7KZS0)
SUMO-conjugating enzyme UBC9 (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I)
Gene: UBE2I

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.594

Property	Details
Experiments	unassigned1304
Identification Methods	two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Hs			1 184
+	Hs
		849315 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		UB2D1_HUMAN (4-157): 3.15e-74: 221: 31.17
+	Hs
		919713 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		UB2D2_HUMAN (4-157): 4.47e-74: 220: 32.47
+	Mm
		761806 TRAF2_MOUSE (1-501): 9.33e-158: 459: 86.83		UB2D3_MOUSE (4-157): 8.42e-73: 217: 31.82
+	Hs
		930181 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	Hs
		849318 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		UB2D1_HUMAN (4-157): 3.15e-74: 221: 31.17
+	Hs
		1024698 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		Q7KZS0_HUMAN (1-184): 1.19e-72: 218: 100.00
+	Hs
		1377466 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UB2D4_HUMAN (4-157): 1.13e-74: 222: 31.82
+	Hs
		849496 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UB2D1_HUMAN (4-157): 3.15e-74: 221: 31.17
+	Mm
		895974 TRAF6_MOUSE (2-498): 2.51e-110: 339: 27.87		UB2D3_MOUSE (4-157): 8.42e-73: 217: 31.82
+	Hs
		919916 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UB2D2_HUMAN (4-157): 4.47e-74: 220: 32.47
+	Hs
		930185 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	Hs
		895966 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UB2D3_HUMAN (4-157): 8.42e-73: 217: 31.82
+	Hs
		930472 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	Hs
		849427 TRAF4_HUMAN (17-498): 1.52e-94: 296: 29.12		UB2D1_HUMAN (4-157): 3.15e-74: 221: 31.17
+	Hs
		1183306 TRAF4_HUMAN (17-498): 1.52e-94: 296: 29.12		Q7KZS0_HUMAN (1-184): 1.19e-72: 218: 100.00
+	Hs
		930374 TRAF4_HUMAN (17-498): 1.52e-94: 296: 29.12		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	Hs
		584907 RO52_HUMAN (28-368): 2.44e-56: 196: 12.68		UB2D1_HUMAN (4-157): 3.15e-74: 221: 31.17
+	Hs
		584916 RO52_HUMAN (28-368): 2.44e-56: 196: 12.68		UB2D3_HUMAN (4-157): 8.42e-73: 217: 31.82
+	Hs
		584902 RO52_HUMAN (28-368): 2.44e-56: 196: 12.68		UB2R1_HUMAN (37-137): 5.12e-22: 90.9: 42.86
+	Hs
		584914 RO52_HUMAN (28-368): 2.44e-56: 196: 12.68		UB2G2_HUMAN (1-137): 1.6e-22: 90.1: 37.16