HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: UBP7 (Q93009)
Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)
Gene: USP7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	31666375, 11279055
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 1102
+	Hs
		129585 TRAF5_HUMAN (7-501): 1.93e-115: 353: 30.90		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1024726 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1273989 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1273839 TRAF4_HUMAN (17-498): 1.52e-94: 296: 29.12		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1023747 TRAF1_HUMAN (130-499): 1.15e-88: 279: 37.44		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1273788 TRI11_HUMAN (24-369): 4.01e-46: 169: 11.71		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1223388 TRI22_HUMAN (27-331): 6.21e-42: 158: 13.68		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1273855 TRIM8_HUMAN (29-350): 1.54e-38: 149: 13.98		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1020772 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		UBP48_HUMAN (206-572): 1.45e-102: 349: 26.90
+	Hs
		1020743 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		U17L2_HUMAN (158-684): 1.09e-103: 338: 19.05
+	Hs
		1024738 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		UBP47_HUMAN (208-737): 3.48e-107: 368: 26.62
+	Hs
		1295925 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP47_HUMAN (208-737): 3.48e-107: 368: 26.62
+	Mm
		936251 TRAF6_MOUSE (2-498): 2.51e-110: 339: 27.87		UBP47_MOUSE (167-737): 1.59e-103: 357: 24.61
+	Hs
		1024693 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		U17L2_HUMAN (158-684): 1.09e-103: 338: 19.05