HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: DHX58 (Q96C10)
ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR)
Gene: DHX58

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29661858
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Hs			1 678
+	Hs
		129586 TRAF5_HUMAN (7-501): 1.93e-115: 353: 30.90		DHX58_HUMAN (1-678): 6.28e-152: 457: 100.00
+	Hs
		1024728 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		DHX58_HUMAN (1-678): 6.28e-152: 457: 100.00
+	Mm
		761822 TRAF2_MOUSE (1-501): 9.33e-158: 459: 86.83		RIGI_MOUSE (1-666): 3.84e-103: 337: 28.88
+	Hs
		1286224 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		DHX58_HUMAN (1-678): 6.28e-152: 457: 100.00
+	Hs
		321891 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89
+	Mm
		1111925 TRAF3_MOUSE (9-501): 1.15e-113: 348: 31.75		SMCA4_MOUSE (3-592): 1.63e-74: 264: 12.94
+	Hs
		134011 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		DDX3X_HUMAN (146-516): 5.67e-56: 203: 16.67
+	Hs
		134263 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		DDX3X_HUMAN (146-516): 5.67e-56: 203: 16.67
+	Mm
		1163172 TRI11_MOUSE (24-369): 2.85e-47: 172: 12.03		RIGI_MOUSE (1-666): 3.84e-103: 337: 28.88
+	Hs
		321932 TRIM6_HUMAN (27-360): 2.88e-47: 172: 13.71		RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89
+	Hs
		1271706 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		DDX17_HUMAN (2-260): 1.9e-42: 165: 17.23
+	Mm
		1142634 TRI25_MOUSE (27-345): 1.19e-42: 162: 14.72		RIGI_MOUSE (1-666): 3.84e-103: 337: 28.88
+	Hs
		321897 TRI25_HUMAN (27-347): 1.26e-39: 153: 12.95		RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89
+	Hs
		134009 TRAF1_HUMAN (130-499): 1.15e-88: 279: 37.44		DDX3X_HUMAN (146-516): 5.67e-56: 203: 16.67
+	Hs
		571424 TRAF1_HUMAN (130-499): 1.15e-88: 279: 37.44		DDX5_HUMAN (2-255): 1.99e-37: 150: 15.21
+	Hs
		1052656 TRI25_HUMAN (27-347): 1.26e-39: 153: 12.95		CHD4_HUMAN (2-626): 2.02e-73: 260: 12.48
+	Hs
		134038 TRI25_HUMAN (27-347): 1.26e-39: 153: 12.95		DDX3X_HUMAN (146-516): 5.67e-56: 203: 16.67
+	Hs
		571451 TRI25_HUMAN (27-347): 1.26e-39: 153: 12.95		DDX5_HUMAN (2-255): 1.99e-37: 150: 15.21
+	Dm
		580736 Q960H6_DROME (80-496): 3.57e-51: 182: 16.55		DDX17_DROME (335-500): 7.82e-16: 83.3: 22.16
+	Dm
		580763 Q9VXG5_DROME (176-496): 3.01e-51: 180: 19.63		DDX17_DROME (335-500): 7.82e-16: 83.3: 22.16