HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: TRAIP (Q9BWF2)
E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein)
Gene: TRAIP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.688

Property	Details
Experiments	25716317, 9104814, 30127245, 17544371
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005654 - nucleoplasm GO:0007165 - signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 469
+	Mm
		761832 TRAF2_MOUSE (1-501): 9.33e-158: 459: 86.83		TRAIP_MOUSE (1-467): 1.17e-109: 334: 79.70
+	Hs
		129594 TRAF5_HUMAN (7-501): 1.93e-115: 353: 30.90		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Hs
		1024752 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Hs
		1314608 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Mm
		936267 TRAF6_MOUSE (2-498): 2.51e-110: 339: 27.87		TRAIP_MOUSE (1-467): 1.17e-109: 334: 79.70
+	Hs
		1023787 TRAF1_HUMAN (130-499): 1.15e-88: 279: 37.44		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Hs
		787905 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		EPS15_HUMAN (3-170): 2.69e-10: 64.9: 14.53
+	Hs
		728474 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		MYH11_HUMAN (29-307): 1.74e-09: 62.5: 17.07
+	Mm
		1141401 TRAF3_MOUSE (9-501): 1.15e-113: 348: 31.75		EP15R_MOUSE (12-185): 1.5e-09: 62.6: 8.62
+	Hs
		725088 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		MYH9_HUMAN (41-307): 2.24e-09: 62.1: 14.47
+	Hs
		724993 TRAF4_HUMAN (17-498): 1.52e-94: 296: 29.12		MYH9_HUMAN (41-307): 2.24e-09: 62.1: 14.47
+	Dm
		1179373 Q960H6_DROME (80-496): 3.57e-51: 182: 16.55		Q7K2X1_DROME (7-294): 2.71e-30: 123: 23.65
+	Dm
		1179391 Q9VXG5_DROME (176-496): 3.01e-51: 180: 19.63		Q7K2X1_DROME (7-294): 2.71e-30: 123: 23.65
+	Hs
		1012561 TRAF7_HUMAN (2-357): 6.49e-45: 169: 14.01		CGNL1_HUMAN (65-280): 2.19e-10: 65.2: 10.66
+	Hs
		522639 TRIM6_HUMAN (27-360): 2.88e-47: 172: 13.71		MYH7_HUMAN (49-380): 4.31e-09: 61.4: 13.22
+	Hs
		528393 TRIM6_HUMAN (27-360): 2.88e-47: 172: 13.71		MYH6_HUMAN (49-290): 9.47e-09: 60.2: 13.77
+	Hs
		1052780 TRI25_HUMAN (27-347): 1.26e-39: 153: 12.95		MYO5C_HUMAN (11-401): 4.42e-11: 67.6: 10.35
+	Hs
		724960 RN125_HUMAN (32-167): 6.6e-34: 129: 21.83		MYH9_HUMAN (41-307): 2.24e-09: 62.1: 14.47