HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: CYLD (Q9NQC7)
Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)
Gene: CYLD

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 0.60 0.715

The method score is based on:

Property Details
Experiments 27591049, 12917691, 28900035, 23405219, 17851586
Identification Methods affinity chromatography technology, two hybrid, enzymatic study, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0019901 - protein kinase binding
GO:0045087 - innate immune response
GO:2001238 - positive regulation of extrinsic apoptotic signaling pathway
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 501
Hs

1 956
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024