HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: AFF4 (Q9UHB7)
AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)
Gene: AFF4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	25416956, 16189514
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0034976 - response to endoplasmic reticulum stress
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 1163
+	Hs
		1020822 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		Q8TAX5_HUMAN (1-363): 3.06e-38: 149: 99.73
+	Hs
		1101024 RN151_HUMAN (17-179): 7.22e-34: 130: 24.41		AFF4_HUMAN (1-1163): 1.3e-124: 413: 100.00
+	Mm
		101444 TRAF3_MOUSE (9-501): 1.15e-113: 348: 31.75		F8VPR5_MOUSE (47-725): 5.12e-30: 132: 12.30
+	Hs
		990867 TRI68_HUMAN (19-368): 3.31e-44: 164: 13.08		ZO1_HUMAN (80-902): 3.89e-34: 145: 12.83
+	Hs
		990906 RN166_HUMAN (11-179): 4.64e-29: 116: 23.26		ZO1_HUMAN (80-902): 3.89e-34: 145: 12.83
+	Hs
		311832 RNF41_HUMAN (18-151): 5.34e-28: 115: 21.13		TACC2_HUMAN (32-1090): 5.83e-15: 82.4: 8.66