HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.765

The method score is based on:

Property Details
Experiments 14743216, 30420664, 32041822, 32707033, 33707416, 36736316, 21903422, 28514442, 29125880, 27135603, 30561431, 10990461, 33961781, 37081115, 20562859, 23007157, 20449947
Identification Methods affinity chromatography technology, enzymatic study, pull down, tandem affinity purification, anti tag coimmunoprecipitation, virotrap
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0019903 - protein phosphatase binding
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024