HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: UBP25 (Q9UHP3)
Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)
Gene: USP25

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	30561431
Identification Methods	affinity chromatography technology, virotrap
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Hs			1 1055
+	Hs
		129604 TRAF5_HUMAN (7-501): 1.93e-115: 353: 30.90		UBP25_HUMAN (1-1055): 0: 1021: 100.00
+	Mm
		883703 TRAF5_MOUSE (7-501): 8.51e-114: 348: 29.25		UBP25_MOUSE (1-1055): 0: 1023: 93.85
+	Mm
		883707 TRAF3_MOUSE (9-501): 1.15e-113: 348: 31.75		UBP25_MOUSE (1-1055): 0: 1023: 93.85
+	Hs
		1024782 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		UBP25_HUMAN (1-1055): 0: 1021: 100.00
+	Mm
		883704 TRAF6_MOUSE (2-498): 2.51e-110: 339: 27.87		UBP25_MOUSE (1-1055): 0: 1023: 93.85
+	Hs
		1355525 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP25_HUMAN (1-1055): 0: 1021: 100.00
+	Hs
		1020772 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		UBP48_HUMAN (157-406): 1.37e-66: 245: 25.86
+	Hs
		800647 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP5_HUMAN (148-656): 1.28e-85: 297: 15.09
+	Hs
		1020743 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		U17L2_HUMAN (563-780): 2.01e-19: 95.4: 18.42
+	Hs
		1020848 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		UBP7_HUMAN (547-758): 1.65e-17: 90.2: 21.78
+	Hs
		271081 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		UBP2_HUMAN (514-660): 9.45e-16: 83.8: 17.69
+	Hs
		1024738 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		UBP47_HUMAN (163-418): 1.83e-39: 161: 18.45
+	Mm
		936251 TRAF6_MOUSE (2-498): 2.51e-110: 339: 27.87		UBP47_MOUSE (163-418): 2e-39: 161: 18.45
+	Hs
		1295925 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP47_HUMAN (163-418): 1.83e-39: 161: 18.45
+	Hs
		129585 TRAF5_HUMAN (7-501): 1.93e-115: 353: 30.90		UBP7_HUMAN (547-758): 1.65e-17: 90.2: 21.78
+	Hs
		1024693 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		U17L2_HUMAN (563-780): 2.01e-19: 95.4: 18.42
+	Hs
		1024726 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		UBP7_HUMAN (547-758): 1.65e-17: 90.2: 21.78
+	Hs
		1273989 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP7_HUMAN (547-758): 1.65e-17: 90.2: 21.78
+	Hs
		271228 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP2_HUMAN (514-660): 9.45e-16: 83.8: 17.69
+	Hs
		1377879 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		UBP3_HUMAN (581-660): 5.95e-11: 68.4: 32.10