HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: Q9UQC1 (Q9UQC1)
Heat shock protein 72
Gene: HSP70-1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 151
+	Hs
		713952 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		HS71L_HUMAN (1-150): 2.61e-76: 240: 91.33
+	Hs
		503989 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Mm
		565424 TRAF6_MOUSE (2-498): 2.51e-110: 339: 27.87		HSP72_MOUSE (1-150): 3.49e-83: 258: 84.87
+	Mm
		571853 TRAF6_MOUSE (2-498): 2.51e-110: 339: 27.87		HS71B_MOUSE (1-150): 8.69e-78: 244: 95.33
+	Mm
		926117 TRAF6_MOUSE (2-498): 2.51e-110: 339: 27.87		HSP7C_MOUSE (1-150): 6.81e-76: 239: 87.33
+	Hs
		1357873 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		Q9UQC1_HUMAN (1-151): 8.55e-83: 241: 100.00
+	Hs
		714101 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		HS71L_HUMAN (1-150): 2.61e-76: 240: 91.33
+	Hs
		505009 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		1023838 TRAF1_HUMAN (130-499): 1.15e-88: 279: 37.44		Q9UQC1_HUMAN (1-151): 8.55e-83: 241: 100.00
+	Hs
		713954 TRAF1_HUMAN (130-499): 1.15e-88: 279: 37.44		HS71L_HUMAN (1-150): 2.61e-76: 240: 91.33
+	Hs
		503998 TRAF1_HUMAN (130-499): 1.15e-88: 279: 37.44		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		135015 TRI38_HUMAN (19-367): 1.53e-53: 189: 14.25		HSP72_HUMAN (1-150): 8.81e-84: 259: 85.53
+	Hs
		563999 RO52_HUMAN (28-368): 2.44e-56: 196: 12.68		HSP76_HUMAN (1-150): 3.19e-78: 245: 85.33
+	Hs
		135010 TRI38_HUMAN (19-367): 1.53e-53: 189: 14.25		HS71L_HUMAN (1-150): 2.61e-76: 240: 91.33
+	Hs
		135007 TRI38_HUMAN (19-367): 1.53e-53: 189: 14.25		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		871567 TRI25_HUMAN (27-347): 1.26e-39: 153: 12.95		HSP72_HUMAN (1-150): 8.81e-84: 259: 85.53
+	Hs
		504715 TRIM6_HUMAN (27-360): 2.88e-47: 172: 13.71		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		713970 TRI25_HUMAN (27-347): 1.26e-39: 153: 12.95		HS71L_HUMAN (1-150): 2.61e-76: 240: 91.33
+	Hs
		504072 TRI25_HUMAN (27-347): 1.26e-39: 153: 12.95		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33