HitPredict

Interactor 1: SUMO5 (G2XKQ0)
Small ubiquitin-related modifier 5 (SUMO-5) (SUMO1 pseudogene 1) (Ubiquitin-like 2) (Ubiquitin-like 6)
Gene: SUMO1P1

Interactor 2: PIAS1 (O75925)
E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)
Gene: PIAS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.40	1.00	0.637

Property	Details
Experiments	27107012
Identification Methods	barcode fusion genetics two hybrid, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rad60-SLD~zf-MIZ
Common GO terms	GO:0005634 - nucleus GO:0016605 - PML body GO:0016925 - protein sumoylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 101 Hs			1 651
+	Hs
		278040 SUMO1_HUMAN (1-101): 4.48e-42: 134: 88.12		PIAS1_HUMAN (1-651): 0: 874: 100.00
+	Hs
		278020 SUMO2_HUMAN (1-97): 9.59e-39: 126: 44.33		PIAS1_HUMAN (1-651): 0: 874: 100.00
+	Hs
		278009 SUMO3_HUMAN (1-97): 8.37e-38: 124: 46.39		PIAS1_HUMAN (1-651): 0: 874: 100.00
+	Hs
		928241 SUMO1_HUMAN (1-101): 4.48e-42: 134: 88.12		PIAS3_HUMAN (1-651): 0: 740: 56.88
+	Hs
		902827 SUMO2_HUMAN (1-97): 9.59e-39: 126: 44.33		PIAS3_HUMAN (1-651): 0: 740: 56.88
+	Mm
		222291 SUMO1_MOUSE (1-101): 4.48e-42: 134: 88.12		PIAS3_MOUSE (1-651): 0: 731: 56.80
+	Hs
		879167 SUMO3_HUMAN (1-97): 8.37e-38: 124: 46.39		PIAS3_HUMAN (1-651): 0: 740: 56.88
+	Hs
		102147 SUMO5_HUMAN (1-101): 7.17e-42: 134: 100.00		PIAS2_HUMAN (1-566): 0: 633: 58.97
+	Hs
		278256 SUMO1_HUMAN (1-101): 4.48e-42: 134: 88.12		PIAS2_HUMAN (1-566): 0: 633: 58.97
+	Hs
		278253 SUMO2_HUMAN (1-97): 9.59e-39: 126: 44.33		PIAS2_HUMAN (1-566): 0: 633: 58.97
+	Hs
		278250 SUMO3_HUMAN (1-97): 8.37e-38: 124: 46.39		PIAS2_HUMAN (1-566): 0: 633: 58.97
+	Rn
		1140374 SUMO3_RAT (1-100): 7.78e-40: 129: 45.00		PIAS2_RAT (1-542): 0: 615: 59.71
+	Hs
		928135 SUMO1_HUMAN (1-101): 4.48e-42: 134: 88.12		PIAS4_HUMAN (2-423): 0: 550: 51.42
+	Hs
		902668 SUMO2_HUMAN (1-97): 9.59e-39: 126: 44.33		PIAS4_HUMAN (2-423): 0: 550: 51.42
+	Hs
		879136 SUMO3_HUMAN (1-97): 8.37e-38: 124: 46.39		PIAS4_HUMAN (2-423): 0: 550: 51.42
+	Rn
		78199 SUMO1_RAT (1-101): 4.48e-42: 134: 88.12		B5DFF9_RAT (2-449): 0: 537: 48.66
+	Rn
		78200 SUMO3_RAT (1-100): 7.78e-40: 129: 45.00		B5DFF9_RAT (2-449): 0: 537: 48.66
+	Rn
		89025 SUMO3_RAT (1-100): 7.78e-40: 129: 45.00		D4AE97_RAT (72-441): 2.98e-75: 262: 20.42
+	At
		1147334 SUMO2_ARATH (5-99): 2.86e-39: 127: 42.11		SIZ1_ARATH (5-615): 2.15e-73: 255: 19.26
+	At
		1147333 SUMO3_ARATH (6-97): 1.34e-37: 124: 38.04		SIZ1_ARATH (5-615): 2.15e-73: 255: 19.26