HitPredict

Interactor 1: SUMO5 (G2XKQ0)
Small ubiquitin-related modifier 5 (SUMO-5) (SUMO1 pseudogene 1) (Ubiquitin-like 2) (Ubiquitin-like 6)
Gene: SUMO1P1

Interactor 2: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rad60-SLD~zf-MIZ
Common GO terms	GO:0005634 - nucleus GO:0016605 - PML body GO:0016925 - protein sumoylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 101 Hs			1 621
+	Hs
		278256 SUMO1_HUMAN (1-101): 4.48e-42: 134: 88.12		PIAS2_HUMAN (1-621): 0: 811: 100.00
+	Hs
		278253 SUMO2_HUMAN (1-97): 9.59e-39: 126: 44.33		PIAS2_HUMAN (1-621): 0: 811: 100.00
+	Hs
		278250 SUMO3_HUMAN (1-97): 8.37e-38: 124: 46.39		PIAS2_HUMAN (1-621): 0: 811: 100.00
+	Rn
		1140374 SUMO3_RAT (1-100): 7.78e-40: 129: 45.00		PIAS2_RAT (1-550): 0: 749: 97.82
+	Hs
		928241 SUMO1_HUMAN (1-101): 4.48e-42: 134: 88.12		PIAS3_HUMAN (1-621): 0: 666: 55.25
+	Mm
		222291 SUMO1_MOUSE (1-101): 4.48e-42: 134: 88.12		PIAS3_MOUSE (1-621): 0: 665: 55.25
+	Hs
		902827 SUMO2_HUMAN (1-97): 9.59e-39: 126: 44.33		PIAS3_HUMAN (1-621): 0: 666: 55.25
+	Hs
		879167 SUMO3_HUMAN (1-97): 8.37e-38: 124: 46.39		PIAS3_HUMAN (1-621): 0: 666: 55.25
+	Hs
		102146 SUMO5_HUMAN (1-101): 7.17e-42: 134: 100.00		PIAS1_HUMAN (1-621): 0: 653: 54.10
+	Hs
		278040 SUMO1_HUMAN (1-101): 4.48e-42: 134: 88.12		PIAS1_HUMAN (1-621): 0: 653: 54.10
+	Hs
		278020 SUMO2_HUMAN (1-97): 9.59e-39: 126: 44.33		PIAS1_HUMAN (1-621): 0: 653: 54.10
+	Hs
		278009 SUMO3_HUMAN (1-97): 8.37e-38: 124: 46.39		PIAS1_HUMAN (1-621): 0: 653: 54.10
+	Rn
		78199 SUMO1_RAT (1-101): 4.48e-42: 134: 88.12		B5DFF9_RAT (2-499): 3.5e-175: 508: 43.80
+	Rn
		78200 SUMO3_RAT (1-100): 7.78e-40: 129: 45.00		B5DFF9_RAT (2-499): 3.5e-175: 508: 43.80
+	Hs
		928135 SUMO1_HUMAN (1-101): 4.48e-42: 134: 88.12		PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32
+	Hs
		902668 SUMO2_HUMAN (1-97): 9.59e-39: 126: 44.33		PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32
+	Hs
		879136 SUMO3_HUMAN (1-97): 8.37e-38: 124: 46.39		PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32
+	At
		1147334 SUMO2_ARATH (5-99): 2.86e-39: 127: 42.11		SIZ1_ARATH (5-521): 5.9e-109: 349: 21.94
+	At
		1147333 SUMO3_ARATH (6-97): 1.34e-37: 124: 38.04		SIZ1_ARATH (5-521): 5.9e-109: 349: 21.94
+	Rn
		89025 SUMO3_RAT (1-100): 7.78e-40: 129: 45.00		D4AE97_RAT (86-460): 7.59e-75: 261: 23.51