HitPredict

Interactor 1: DLG1 (Q12959)
Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)
Gene: DLG1

Interactor 2: ARHG8 (Q7Z628)
Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8)
Gene: NET1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.941

Property	Details
Experiments	32203420, 19586902, 17938206, 24550280, 30126976, unassigned2213
Identification Methods	affinity chromatography technology, pull down, phage display, p8 filamentous phage display, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PH~SH3_1, RhoGEF~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 904 Hs			1 596
+	Hs
		1191348 DLG3_HUMAN (139-904): 0: 585: 66.28		ARHG8_HUMAN (1-596): 6.4e-144: 431: 100.00
+	Hs
		1021546 DLG1_HUMAN (1-904): 0: 725: 100.00		ARHGQ_HUMAN (24-496): 8.06e-81: 273: 18.33
+	Hs
		1021513 DLG1_HUMAN (1-904): 0: 725: 100.00		ARHGG_HUMAN (121-496): 6.34e-74: 252: 19.80
+	Hs
		1271019 DLG3_HUMAN (139-904): 0: 585: 66.28		ARHGQ_HUMAN (24-496): 8.06e-81: 273: 18.33
+	Hs
		279898 PALS2_HUMAN (421-899): 2.36e-108: 346: 23.48		TRIO_HUMAN (151-567): 5.08e-60: 219: 17.48
+	Hs
		942359 DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64		ARHG8_HUMAN (1-596): 6.4e-144: 431: 100.00
+	Hs
		1049995 SCRIB_HUMAN (217-396): 1.59e-23: 109: 41.49		ARHG8_HUMAN (1-596): 6.4e-144: 431: 100.00
+	Hs
		1050065 SCRIB_HUMAN (217-396): 1.59e-23: 109: 41.49		ECT2_HUMAN (71-596): 8.41e-88: 293: 17.50
+	Hs
		159251 CSKP_HUMAN (19-360): 4.23e-28: 124: 10.64		ARHGQ_HUMAN (24-496): 8.06e-81: 273: 18.33
+	Mm
		88351 DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07		D3YYY8_MOUSE (24-496): 2.49e-80: 272: 18.74
+	Hs
		1050027 SCRIB_HUMAN (217-396): 1.59e-23: 109: 41.49		ARHGQ_HUMAN (24-496): 8.06e-81: 273: 18.33
+	Hs
		1333783 ZO2_HUMAN (435-711): 1.38e-13: 77.2: 17.13		ECT2_HUMAN (71-596): 8.41e-88: 293: 17.50
+	Hs
		1049974 SCRIB_HUMAN (217-396): 1.59e-23: 109: 41.49		ARHGG_HUMAN (121-496): 6.34e-74: 252: 19.80
+	Mm
		57852 DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07		KALRN_MOUSE (147-567): 2.72e-58: 214: 16.90
+	Mm
		57873 DLG2_MOUSE (393-627): 3.09e-21: 101: 24.48		KALRN_MOUSE (147-567): 2.72e-58: 214: 16.90
+	Hs
		1167833 ZO2_HUMAN (435-711): 1.38e-13: 77.2: 17.13		DNMBP_HUMAN (174-354): 1.94e-11: 69.3: 28.42