HitPredict

Interactor 1: TP4A2 (Q12974)
Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2)
Gene: PTP4A2

Interactor 2: CNNM2 (Q9H8M5)
Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2)
Gene: CNNM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.930

Property	Details
Experiments	28514442, 27432908, 28330616, 28675297, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CBS~Y_phosphatase
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 167 Hs			1 875
+	Hs
		1274603 TP4A1_HUMAN (1-167): 1.41e-66: 202: 87.65		CNNM2_HUMAN (1-875): 0: 1254: 100.00
+	Hs
		1021801 TP4A2_HUMAN (1-167): 6.88e-68: 205: 100.00		CNNM4_HUMAN (60-867): 0: 922: 59.98
+	Hs
		1159772 TP4A1_HUMAN (1-167): 1.41e-66: 202: 87.65		CNNM4_HUMAN (60-867): 0: 922: 59.98
+	Hs
		1021828 TP4A2_HUMAN (1-167): 6.88e-68: 205: 100.00		CNNM1_HUMAN (74-866): 0: 839: 48.59
+	Hs
		1274604 TP4A1_HUMAN (1-167): 1.41e-66: 202: 87.65		CNNM1_HUMAN (74-866): 0: 839: 48.59
+	Dm
		2649 PRL1_DROME (3-167): 1.05e-58: 182: 56.63		UEX_DROME (74-871): 0: 689: 41.30
+	Hs
		1021810 TP4A2_HUMAN (1-167): 6.88e-68: 205: 100.00		CNNM3_HUMAN (276-865): 0: 572: 48.74
+	Hs
		1242821 TP4A1_HUMAN (1-167): 1.41e-66: 202: 87.65		CNNM3_HUMAN (276-865): 0: 572: 48.74
+	Hs
		260582 TP4A3_HUMAN (1-166): 1.45e-64: 197: 77.52		CNNM3_HUMAN (276-865): 0: 572: 48.74
+	Hs
		1144582 TENS2_HUMAN (1-149): 9.18e-45: 158: 13.86		CNNM3_HUMAN (276-865): 0: 572: 48.74