Interactor 1: NPRL3 (Q12980)
GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA)
Gene: NPRL3

Interactor 2: NPRL2 (Q8WTW4)
GATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4)
Gene: NPRL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.963

The method score is based on:

Property Details
Experiments 28199315, 23723238, 28514442, 28199306, 27684187, 33961781, 19521502
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains NPR2~NPR3
Common GO terms GO:0005096 - GTPase activator activity
GO:0005765 - lysosomal membrane
GO:0010508 - positive regulation of autophagy
GO:0032007 - negative regulation of TOR signaling
GO:0034198 - cellular response to amino acid starvation
and 2 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 569
Hs

1 380
+ Dm
+ Sp

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Last updated: 15 Jul 2024