HitPredict

Interactor 1: HSPB3 (Q12988)
Heat shock protein beta-3 (HspB3) (Heat shock 17 kDa protein) (HSP 17) (Heat shock protein family B member 3) (Protein 3)
Gene: HSPB3

Interactor 2: HSPB8 (Q9UJY1)
Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22)
Gene: HSPB8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	16225851
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HSP20~HSP20
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 150 Hs			1 196
+	Hs
		359087 CRYAB_HUMAN (13-147): 1.32e-47: 153: 27.41		HSPB8_HUMAN (1-196): 7.92e-71: 214: 100.00
+	Hs
		358699 CRYAA_HUMAN (13-145): 2.73e-48: 155: 30.83		HSPB1_HUMAN (1-179): 9.77e-63: 194: 36.67
+	Hs
		358950 CRYAB_HUMAN (13-147): 1.32e-47: 153: 27.41		HSPB1_HUMAN (1-179): 9.77e-63: 194: 36.67
+	Rn
		621311 CRYAB_RAT (13-149): 1.86e-48: 155: 27.01		HSPB1_RAT (1-179): 4.16e-61: 190: 36.41
+	Hs
		358697 CRYAA_HUMAN (13-145): 2.73e-48: 155: 30.83		CRYAB_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Hs
		358941 CRYAA_HUMAN (13-145): 2.73e-48: 155: 30.83		V9HW27_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Hs
		358696 CRYAA_HUMAN (13-145): 2.73e-48: 155: 30.83		CRYAA_HUMAN (6-187): 8.59e-53: 168: 23.53
+	Hs
		1378434 V9HW27_HUMAN (13-147): 1.32e-47: 153: 27.41		V9HW27_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Hs
		358943 CRYAB_HUMAN (13-147): 1.32e-47: 153: 27.41		CRYAB_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Bt
		358695 CRYAB_BOVIN (13-149): 2.78e-48: 155: 27.74		CRYAA_BOVIN (6-190): 1.34e-51: 165: 24.32
+	Dm
		359118 HSP23_DROME (1-150): 6.4e-48: 154: 29.14		HSP26_DROME (10-193): 1.59e-49: 161: 21.20
+	Hs
		147843 CRYAB_HUMAN (13-147): 1.32e-47: 153: 27.41		HSPB6_HUMAN (5-166): 4.57e-44: 146: 31.10
+	Hs
		358767 CRYAA_HUMAN (13-145): 2.73e-48: 155: 30.83		HSPB2_HUMAN (1-170): 5.01e-42: 141: 25.88
+	Hs
		1022259 HSPB3_HUMAN (1-150): 7.66e-48: 153: 100.00		HSPB2_HUMAN (1-170): 5.01e-42: 141: 25.88
+	Hs
		359021 CRYAB_HUMAN (13-147): 1.32e-47: 153: 27.41		HSPB2_HUMAN (1-170): 5.01e-42: 141: 25.88
+	Dm
		359119 HSP23_DROME (1-150): 6.4e-48: 154: 29.14		HSP27_DROME (8-192): 6.11e-41: 139: 26.98
+	Dm
		359124 HSP23_DROME (1-150): 6.4e-48: 154: 29.14		HSP6C_DROME (35-193): 2.57e-40: 137: 26.09
+	Dm
		359096 HSP23_DROME (1-150): 6.4e-48: 154: 29.14		HSP22_DROME (21-192): 4.46e-32: 115: 23.56