HitPredict - High confidence protein-protein interactions

Interactor 1: STK4 (Q13043)
Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
Gene: STK4

Interactor 2: STK4 (Q13043)
Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
Gene: STK4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.980

Property	Details
Experiments	21572393, 26578655, 28205554, 8702870, 22863277, 17517604, 20562859, 21730291, 21516123, 23386615
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, two hybrid, pull down, enzymatic study, nuclear magnetic resonance, light scattering, cross-linking study, molecular sieving, anti tag coimmunoprecipitation and 2 others more... coimmunoprecipitation, protein kinase assay
Interaction Type	physical association, direct interaction, association, phosphorylation reaction

Property	Details
Interacting Pfam domains	Mst1_SARAH~Mst1_SARAH, Pkinase~Pkinase
Common GO terms	GO:0000287 - magnesium ion binding GO:0000902 - cell morphogenesis GO:0001569 - branching involved in blood vessel morphogenesis GO:0001841 - neural tube formation GO:0001934 - positive regulation of protein phosphorylation and 45 others more... GO:0003157 - endocardium development GO:0004672 - protein kinase activity GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0006606 - protein import into nucleus GO:0006915 - apoptotic process GO:0007165 - signal transduction GO:0007417 - central nervous system development GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors GO:0016604 - nuclear body GO:0018105 - peptidyl-serine phosphorylation GO:0030216 - keratinocyte differentiation GO:0032092 - positive regulation of protein binding GO:0032991 - protein-containing complex GO:0033138 - positive regulation of peptidyl-serine phosphorylation GO:0035265 - organ growth GO:0035329 - hippo signaling GO:0035556 - intracellular signal transduction GO:0042803 - protein homodimerization activity GO:0043065 - positive regulation of apoptotic process GO:0043408 - regulation of MAPK cascade GO:0043539 - protein serine/threonine kinase activator activity GO:0045600 - positive regulation of fat cell differentiation GO:0046621 - negative regulation of organ growth GO:0046777 - protein autophosphorylation GO:0050673 - epithelial cell proliferation GO:0050680 - negative regulation of epithelial cell proliferation GO:0050821 - protein stabilization GO:0051262 - protein tetramerization GO:0060070 - canonical Wnt signaling pathway GO:0060215 - primitive hemopoiesis GO:0060706 - cell differentiation involved in embryonic placenta development GO:0060800 - regulation of cell differentiation involved in embryonic placenta development GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0090090 - negative regulation of canonical Wnt signaling pathway GO:0097284 - hepatocyte apoptotic process GO:0106310 - protein serine kinase activity GO:1902043 - positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1903945 - positive regulation of hepatocyte apoptotic process GO:1904237 - positive regulation of substrate-dependent cell migration, cell attachment to substrate
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1	487
Hs

1	487

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024