HitPredict

Interactor 1: MKRN3 (Q13064)
Probable E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127)
Gene: MKRN3

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0016567 - protein ubiquitination
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 507 Hs			1 147
+	Hs
		849317 MKRN3_HUMAN (1-507): 0: 599: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919716 MKRN3_HUMAN (1-507): 0: 599: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895784 MKRN3_HUMAN (1-507): 0: 599: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		1023535 MKRN3_HUMAN (1-507): 0: 599: 100.00		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		1023522 MKRN3_HUMAN (1-507): 0: 599: 100.00		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		851809 MKRN3_HUMAN (1-507): 0: 599: 100.00		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		896430 MKRN3_HUMAN (1-507): 0: 599: 100.00		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Hs
		1355338 MKRN1_HUMAN (95-507): 0: 539: 53.61		UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00
+	Hs
		849477 MKRN1_HUMAN (95-507): 0: 539: 53.61		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		895942 MKRN1_HUMAN (95-507): 0: 539: 53.61		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		1327018 MKRN2_HUMAN (94-477): 1.96e-161: 465: 34.88		UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00
+	Hs
		849442 MKRN2_HUMAN (94-477): 1.96e-161: 465: 34.88		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919857 MKRN2_HUMAN (94-477): 1.96e-161: 465: 34.88		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Dm
		639406 Q9VP20_DROME (98-450): 1.42e-123: 368: 36.84		UBCD1_DROME (1-147): 4.66e-82: 239: 92.52