HitPredict

Interactor 1: G3V1L9 (G3V1L9)
Tight junction protein 1
Gene: TJP1

Interactor 2: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	26496610
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Metallophos~PDZ, PDZ~STPPase_N
Common GO terms	GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1861 Hs			1 327
+	Hs
		906425 ZO1_HUMAN (95-1861): 0: 1006: 98.47		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Hs
		159165 CSKP_HUMAN (356-898): 3.11e-86: 306: 14.63		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Mm
		906652 DLG4_MOUSE (32-240): 1.3e-25: 116: 19.91		PP1B_MOUSE (1-327): 0: 597: 100.00
+	Mm
		906274 DLG4_MOUSE (32-240): 1.3e-25: 116: 19.91		PP1A_MOUSE (1-326): 0: 576: 88.49
+	Dm
		113980 M9PB30_DROME (1112-1791): 6.03e-26: 120: 14.33		PP1B_DROME (1-322): 0: 568: 90.37
+	Hs
		906059 DLG3_HUMAN (385-1014): 6.15e-21: 102: 12.91		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		906454 SCRIB_HUMAN (506-597): 1.96e-11: 71.8: 29.00		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Mm
		926531 DLG3_MOUSE (397-1014): 1.88e-18: 94.2: 13.29		PP1G_MOUSE (1-327): 0: 569: 86.89
+	Hs
		905921 DLG2_HUMAN (437-605): 1.12e-14: 81.9: 19.77		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		737775 DLG1_HUMAN (7-208): 6.45e-16: 86.2: 18.78		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		905890 SCRIB_HUMAN (506-597): 1.96e-11: 71.8: 29.00		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		737799 SCRIB_HUMAN (506-597): 1.96e-11: 71.8: 29.00		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Mm
		915328 DLG4_MOUSE (32-240): 1.3e-25: 116: 19.91		PP2AB_MOUSE (8-303): 1.26e-176: 492: 46.13
+	Hs
		930919 UNC5B_HUMAN (1727-1825): 3.31e-14: 80.5: 43.43		PP2AA_HUMAN (8-303): 2.77e-176: 491: 45.79