HitPredict

Interactor 1: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Interactor 2: M3K14 (Q99558)
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
Gene: MAP3K14

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	9275204, 23543740, 11278268, 20385093, 15084608
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 416 Hs			1 947
+	Hs
		1020885 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		M3K14_HUMAN (1-947): 0: 799: 100.00
+	Mm
		761844 TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77		M3K14_MOUSE (1-947): 0: 758: 83.98
+	Hs
		1304544 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		M3K14_HUMAN (1-947): 0: 799: 100.00
+	Hs
		129589 TRAF5_HUMAN (14-261): 1.36e-16: 83.8: 13.91		M3K14_HUMAN (1-947): 0: 799: 100.00
+	Hs
		1023647 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		AAPK1_HUMAN (374-909): 2.62e-124: 390: 17.48
+	Hs
		1020632 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		AAPK1_HUMAN (374-909): 2.62e-124: 390: 17.48
+	Hs
		682088 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		AKT1_HUMAN (286-713): 3.76e-131: 405: 19.33
+	Mm
		682105 TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51		AKT1_MOUSE (286-713): 1.66e-131: 406: 20.22
+	Hs
		1025247 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		AAPK1_HUMAN (374-909): 2.62e-124: 390: 17.48
+	Hs
		850645 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		KS6A3_HUMAN (319-656): 2.54e-97: 324: 20.46
+	Hs
		1023147 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		STK4_HUMAN (405-650): 2.6e-99: 321: 30.80
+	Mm
		578260 TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51		KS6A3_MOUSE (319-656): 2.54e-97: 324: 20.46
+	Hs
		1023648 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		STK3_HUMAN (405-647): 1.3e-20: 98.2: 31.73
+	Hs
		783322 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		M3K8_HUMAN (379-647): 2.68e-29: 124: 30.66
+	Mm
		101507 TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77		F8VQ72_MOUSE (370-643): 4.83e-24: 111: 30.52
+	Hs
		1020637 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		M3K1_HUMAN (370-643): 2.05e-24: 112: 30.52
+	Hs
		783332 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		M3K8_HUMAN (379-647): 2.68e-29: 124: 30.66
+	Mm
		101510 TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51		F8VQ72_MOUSE (370-643): 4.83e-24: 111: 30.52
+	Hs
		1306410 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		M3K3_HUMAN (373-612): 7.37e-23: 106: 32.14
+	Mm
		936233 TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51		M3K3_MOUSE (373-612): 5.42e-23: 106: 32.14