HitPredict

Interactor 1: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 533 Hs			1 1308
+	Hs
		1070974 TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32		ERBB4_HUMAN (1-1308): 0: 1406: 100.00
+	Hs
		601909 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383773 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		338356 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		383868 CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		601960 BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383899 BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		601934 TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383851 TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		601935 TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383853 TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Rn
		94037 F1LN91_RAT (103-512): 2.27e-33: 137: 12.39		Q9QX70_RAT (24-1286): 0: 1074: 48.93
+	Hs
		338635 CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		338753 BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		338550 TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		338552 TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		992571 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		ACK1_HUMAN (697-970): 1.51e-54: 209: 40.43
+	Hs
		796468 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		ZAP70_HUMAN (724-967): 1.42e-54: 204: 41.63
+	Gg
		94506 BLNK_CHICK (52-520): 2.03e-31: 129: 21.42		KSYK_CHICK (724-967): 2.76e-56: 209: 41.70
+	Rn
		94036 F1LN91_RAT (103-512): 2.27e-33: 137: 12.39		INSR_RAT (353-660): 1.09e-31: 137: 19.05