HitPredict

Interactor 1: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Interactor 2: SHB (Q15464)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	12084069
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0005829 - cytosol GO:0050852 - T cell receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 533 Hs			1 509
+	Hs
		666094 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		209043 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		NCK2_HUMAN (157-505): 7.36e-63: 211: 17.45
+	Hs
		522951 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		442821 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		HCK_HUMAN (261-507): 1.14e-54: 193: 15.75
+	Hs
		557674 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Hs
		412165 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Mm
		1141384 LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98		NCK1_MOUSE (157-504): 4.76e-55: 191: 14.80
+	Mm
		763395 LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98		FYN_MOUSE (283-506): 1.94e-53: 190: 15.16
+	Hs
		924534 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		209129 BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28		NCK2_HUMAN (157-505): 7.36e-63: 211: 17.45
+	Hs
		275193 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		GRAP2_HUMAN (354-490): 4.56e-18: 87.3: 24.64
+	Mm
		536209 CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57		FGR_MOUSE (282-509): 2.9e-57: 200: 17.65
+	Hs
		1144541 TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32		TENS2_HUMAN (43-506): 4.48e-57: 207: 15.20
+	Mm
		763411 CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57		FYN_MOUSE (283-506): 1.94e-53: 190: 15.16
+	Hs
		557750 BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Mm
		1141385 LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98		GRAP_MOUSE (354-506): 5.69e-18: 84.6: 19.36
+	Hs
		924670 CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		924727 BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		924632 TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		275217 BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28		GRAP2_HUMAN (354-490): 4.56e-18: 87.3: 24.64