HitPredict

Interactor 1: CSN1 (Q13098)
COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH)
Gene: GPS1

Interactor 2: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.730

Property	Details
Experiments	11337588, 16036220, 29103612, 34237211, 21169563, 21145461
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 491 Hs			1 776
+	Hs
		1024160 CSN1_HUMAN (1-491): 9.03e-163: 471: 100.00		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		1024161 CSN1_HUMAN (1-491): 9.03e-163: 471: 100.00		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		1024159 CSN1_HUMAN (1-491): 9.03e-163: 471: 100.00		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		87385 C9JFE4_HUMAN (17-491): 2.39e-149: 436: 99.16		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		1024158 CSN1_HUMAN (1-491): 9.03e-163: 471: 100.00		CUL2_HUMAN (13-776): 0: 720: 35.98
+	Mm
		897343 CSN2_MOUSE (72-458): 4.14e-76: 247: 14.07		CUL1_MOUSE (1-776): 0: 912: 99.87
+	Hs
		897242 CSN2_HUMAN (72-458): 4.14e-76: 247: 14.07		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		1024200 CSN1_HUMAN (1-491): 9.03e-163: 471: 100.00		CUL5_HUMAN (2-776): 0: 622: 28.85
+	Hs
		1041600 PSMD6_HUMAN (65-454): 2.66e-104: 318: 21.03		CUL3_HUMAN (9-776): 0: 748: 30.47
+	At
		1258869 CSN2_ARATH (72-456): 1.65e-88: 279: 13.30		CUL3A_ARATH (7-776): 0: 781: 30.21
+	At
		799476 CSN1_ARATH (25-471): 2.93e-110: 335: 44.12		CUL1_ARATH (10-776): 0: 722: 30.29
+	Hs
		888361 EIF3E_HUMAN (41-475): 8.35e-99: 306: 13.51		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		897245 CSN2_HUMAN (72-458): 4.14e-76: 247: 14.07		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		897246 CSN2_HUMAN (72-458): 4.14e-76: 247: 14.07		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	At
		1258866 CSN2_ARATH (72-456): 1.65e-88: 279: 13.30		CUL1_ARATH (10-776): 0: 722: 30.29
+	Sp
		142912 CSN1_SCHPO (43-485): 2.4e-84: 268: 25.45		CUL1_SCHPO (1-776): 0: 733: 40.92
+	Hs
		897244 CSN2_HUMAN (72-458): 4.14e-76: 247: 14.07		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Ce
		1088888 CSN1_CAEEL (9-477): 1.63e-97: 307: 25.29		CUL3_CAEEL (10-776): 0: 670: 27.06
+	Hs
		897243 CSN2_HUMAN (72-458): 4.14e-76: 247: 14.07		CUL2_HUMAN (13-776): 0: 720: 35.98
+	Sp
		292919 CSN1_SCHPO (43-485): 2.4e-84: 268: 25.45		CUL3_SCHPO (5-776): 0: 635: 26.43