HitPredict

Interactor 1: UBP4 (Q13107)
Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog)
Gene: USP4

Interactor 2: UBP32 (Q8NFA0)
Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32)
Gene: USP32

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19615732
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DUSP~DUSP, DUSP~Ubiquitin_3, Ubiquitin_3~Ubiquitin_3, UCH~UCH
Common GO terms	GO:0004843 - cysteine-type deubiquitinase activity GO:0005829 - cytosol GO:0006508 - proteolysis GO:0016579 - protein deubiquitination GO:1904263 - positive regulation of TORC1 signaling
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 963 Hs			1 1604
+	Hs
		1244193 UBP15_HUMAN (1-924): 0: 749: 58.17		UBP32_HUMAN (1-1604): 0: 1299: 100.00
+	Hs
		1024353 UBP4_HUMAN (1-963): 0: 908: 100.00		Q4VC15_HUMAN (1217-1604): 8.05e-99: 325: 100.00
+	Hs
		1024442 UBP4_HUMAN (1-963): 0: 908: 100.00		UBP21_HUMAN (718-918): 9.16e-27: 119: 32.74
+	Hs
		1024318 UBP4_HUMAN (1-963): 0: 908: 100.00		UBP4_HUMAN (1385-1570): 2.71e-25: 116: 19.79
+	Hs
		301380 UBP4_HUMAN (1-963): 0: 908: 100.00		UBP19_HUMAN (1442-1590): 2.03e-22: 107: 18.99
+	Hs
		850023 UBP4_HUMAN (1-963): 0: 908: 100.00		UBP11_HUMAN (1442-1576): 1.82e-22: 107: 22.30
+	Hs
		1024450 UBP4_HUMAN (1-963): 0: 908: 100.00		UBP15_HUMAN (897-1072): 8.68e-12: 72.4: 6.74
+	Hs
		1356322 UBP15_HUMAN (1-924): 0: 749: 58.17		UBP21_HUMAN (718-918): 9.16e-27: 119: 32.74
+	Hs
		850247 UBP15_HUMAN (1-924): 0: 749: 58.17		UBP11_HUMAN (1442-1576): 1.82e-22: 107: 22.30
+	Hs
		1377299 UBP15_HUMAN (1-924): 0: 749: 58.17		UBP20_HUMAN (1474-1570): 2.3e-21: 103: 28.00
+	Hs
		1257047 UBP15_HUMAN (1-924): 0: 749: 58.17		UBP33_HUMAN (860-1079): 3.75e-21: 102: 8.97
+	Hs
		271227 UBP15_HUMAN (1-924): 0: 749: 58.17		UBP2_HUMAN (1219-1311): 1.28e-14: 80.9: 33.33
+	Hs
		849956 UBP11_HUMAN (6-937): 0: 717: 44.60		UBP11_HUMAN (1442-1576): 1.82e-22: 107: 22.30
+	Hs
		1377844 UBP15_HUMAN (1-924): 0: 749: 58.17		UBP15_HUMAN (897-1072): 8.68e-12: 72.4: 6.74
+	Mm
		1246961 UBP15_MOUSE (1-924): 0: 745: 57.75		UBP15_MOUSE (897-1072): 7.32e-12: 72.8: 7.25
+	Hs
		777091 UBP15_HUMAN (1-924): 0: 749: 58.17		UBP8_HUMAN (1510-1568): 1.42e-09: 65.1: 38.33