HitPredict

Interactor 1: UBP4 (Q13107)
Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog)
Gene: USP4

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	22262844, 30194441, 22029577
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 963 Hs			1 522
+	Mm
		715072 UBP4_MOUSE (1-963): 0: 895: 90.76		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Hs
		1020630 UBP4_HUMAN (1-963): 0: 908: 100.00		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1377846 UBP15_HUMAN (1-924): 0: 749: 58.17		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		1024331 UBP4_HUMAN (1-963): 0: 908: 100.00		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		584941 UBP4_HUMAN (1-963): 0: 908: 100.00		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		1313391 UBP15_HUMAN (1-924): 0: 749: 58.17		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Rn
		88506 UBP11_RAT (6-963): 0: 705: 43.44		D3Z9G0_RAT (20-501): 1.11e-86: 280: 22.40
+	Hs
		1290911 UBP15_HUMAN (1-924): 0: 749: 58.17		TRI11_HUMAN (59-404): 1.13e-49: 179: 12.75
+	Hs
		301460 UBP19_HUMAN (183-937): 6.87e-148: 474: 30.87		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		1052814 UBP15_HUMAN (1-924): 0: 749: 58.17		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		585101 UBP15_HUMAN (1-924): 0: 749: 58.17		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		537147 UBP15_HUMAN (1-924): 0: 749: 58.17		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1377848 UBP15_HUMAN (1-924): 0: 749: 58.17		TRI17_HUMAN (58-408): 7.59e-43: 160: 11.86
+	Hs
		1318721 UBP15_HUMAN (1-924): 0: 749: 58.17		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		536761 UBP11_HUMAN (6-937): 0: 717: 44.60		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1257048 UBP33_HUMAN (203-962): 7.87e-114: 374: 18.72		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		1377300 UBP20_HUMAN (203-962): 3.45e-110: 363: 17.72		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		1020995 UBP20_HUMAN (203-962): 3.45e-110: 363: 17.72		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		301359 UBP19_HUMAN (183-937): 6.87e-148: 474: 30.87		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		1198275 UBP37_HUMAN (164-938): 7.6e-90: 309: 14.43		TRIM4_HUMAN (61-336): 6.36e-43: 161: 12.90