HitPredict

Interactor 1: G3V617 (G3V617)
Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha)
Gene: Mapk14

Interactor 2: Q498S1 (Q498S1)
Map2k3 protein
Gene: Map2k3

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16407200
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0038066 - p38MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Rn			1 107
+	Hs
		153134 MK14_HUMAN (1-360): 1.84e-156: 445: 99.17		MP2K7_HUMAN (5-105): 3.53e-42: 144: 37.26
+	Mm
		814040 MK14_MOUSE (1-360): 6.65e-157: 446: 99.72		MP2K6_MOUSE (1-105): 2.07e-40: 137: 78.10
+	Hs
		800984 MK14_HUMAN (1-360): 1.84e-156: 445: 99.17		MP2K4_HUMAN (1-105): 2.65e-38: 133: 43.52
+	Mm
		140323 MK14_MOUSE (1-360): 6.65e-157: 446: 99.72		MP2K3_MOUSE (1-107): 8.61e-38: 131: 100.00
+	Hs
		805428 MK14_HUMAN (1-360): 1.84e-156: 445: 99.17		MP2K3_HUMAN (1-107): 9.99e-38: 131: 98.13
+	Hs
		854732 MK14_HUMAN (1-360): 1.84e-156: 445: 99.17		MP2K6_HUMAN (1-105): 1.74e-35: 125: 80.95
+	At
		1106332 MPK4_ARATH (1-352): 1.19e-148: 426: 48.46		M2K1_ARATH (5-101): 8.6e-41: 139: 37.86
+	At
		1106354 MPK4_ARATH (1-352): 1.19e-148: 426: 48.46		M2K6_ARATH (5-99): 5.14e-41: 139: 41.58
+	At
		1106294 MPK4_ARATH (1-352): 1.19e-148: 426: 48.46		CDPK3_ARATH (2-105): 1.46e-35: 128: 14.95
+	At
		1105516 MPK4_ARATH (1-352): 1.19e-148: 426: 48.46		M3K1_ARATH (1-87): 1.5e-34: 126: 35.63
+	At
		1106388 MPK4_ARATH (1-352): 1.19e-148: 426: 48.46		M2K2_ARATH (3-101): 2.58e-35: 125: 39.05
+	Hs
		647503 MK03_HUMAN (11-354): 1.78e-144: 415: 48.15		MP2K3_HUMAN (1-107): 9.99e-38: 131: 98.13
+	Hs
		854720 MK12_HUMAN (1-351): 5.2e-146: 418: 62.99		MP2K6_HUMAN (1-105): 1.74e-35: 125: 80.95
+	At
		1114822 MPK16_ARATH (2-360): 7e-141: 412: 39.46		CDPK8_ARATH (2-105): 1.88e-35: 128: 18.69
+	Dm
		247427 MK38B_DROME (1-352): 5.87e-144: 413: 70.14		O62602_DROME (1-104): 1.48e-36: 127: 51.92
+	Sc
		434744 HOG1_YEAST (3-350): 2.56e-142: 412: 51.29		PBS2_YEAST (1-104): 1.84e-34: 126: 38.68
+	Hs
		1026805 MK07_HUMAN (13-349): 4.38e-144: 429: 45.67		MP2K5_HUMAN (5-84): 2.1e-20: 85.9: 50.00
+	Hs
		647547 MK03_HUMAN (11-354): 1.78e-144: 415: 48.15		MP2K1_HUMAN (5-104): 5.94e-16: 73.6: 30.50
+	Hs
		647488 MK03_HUMAN (11-354): 1.78e-144: 415: 48.15		MP2K2_HUMAN (5-103): 1.31e-13: 66.6: 27.08
+	Sc
		420018 HOG1_YEAST (3-350): 2.56e-142: 412: 51.29		STE7_YEAST (5-94): 4.36e-14: 68.2: 38.95