HitPredict

Interactor 1: TRAF3 (Q13114)
TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)
Gene: TRAF3

Interactor 2: TNR14 (Q92956)
Tumor necrosis factor receptor superfamily member 14 (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD antigen CD270)
Gene: TNFRSF14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.608

Property	Details
Experiments	9162022, 10799510
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 568 Hs			1 283
+	Hs
		584394 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR1A_HUMAN (25-277): 1.97e-62: 205: 19.39
+	Mm
		192587 TRAF3_MOUSE (1-568): 3.65e-163: 478: 96.13		TNR11_MOUSE (22-225): 1.45e-53: 185: 25.00
+	Mm
		648958 TRAF3_MOUSE (1-568): 3.65e-163: 478: 96.13		TNR5_MOUSE (22-225): 2.69e-54: 179: 29.13
+	Hs
		1024798 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR11_HUMAN (38-224): 3.77e-49: 173: 26.80
+	Hs
		591320 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR1B_HUMAN (30-214): 2e-49: 171: 26.98
+	Hs
		639578 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR5_HUMAN (31-225): 3.22e-51: 171: 28.28
+	Hs
		738661 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR3_HUMAN (31-211): 3.54e-48: 167: 28.72
+	Mm
		838553 TRAF3_MOUSE (1-568): 3.65e-163: 478: 96.13		TNR3_MOUSE (31-207): 2.66e-42: 151: 28.65
+	Hs
		632265 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR6_HUMAN (44-164): 2.33e-34: 128: 30.89
+	Mm
		812913 TRAF3_MOUSE (1-568): 3.65e-163: 478: 96.13		TNR4_MOUSE (41-213): 3.68e-31: 118: 27.01
+	Hs
		645797 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		CD27_HUMAN (23-266): 2.68e-29: 113: 14.84
+	Mm
		192584 TRAF5_MOUSE (10-567): 4.83e-133: 401: 41.36		TNR11_MOUSE (22-225): 1.45e-53: 185: 25.00
+	Hs
		796825 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR4_HUMAN (42-204): 3.08e-25: 102: 25.15
+	Mm
		591448 TRAF3_MOUSE (1-568): 3.65e-163: 478: 96.13		TNR9_MOUSE (54-210): 3.9e-24: 99: 26.58
+	Hs
		989744 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR9_HUMAN (48-208): 1.68e-23: 98: 25.31
+	Hs
		1024763 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR27_HUMAN (41-151): 1.72e-20: 90.7: 29.66
+	Hs
		1024787 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		EDAR_HUMAN (1-161): 1.21e-19: 89.9: 21.98
+	Mm
		838552 TRAF5_MOUSE (10-567): 4.83e-133: 401: 41.36		TNR3_MOUSE (31-207): 2.66e-42: 151: 28.65
+	Hs
		661045 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR8_HUMAN (59-176): 4.18e-13: 71: 22.03
+	Hs
		436620 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR16_HUMAN (24-125): 1.13e-12: 69.5: 28.70