HitPredict

Interactor 1: RLF (Q13129)
Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein)
Gene: RLF

Interactor 2: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	27705803, 34079125, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1914 Hs			1 183
+	Hs
		800363 RLF_HUMAN (26-1914): 0: 1162: 97.36		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		949768 RLF_HUMAN (26-1914): 0: 1162: 97.36		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Mm
		56880 A2A7F4_MOUSE (28-1914): 0: 1103: 86.72		Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00
+	Mm
		56878 A2A7F4_MOUSE (28-1914): 0: 1103: 86.72		CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89
+	Mm
		56877 A2A7F4_MOUSE (28-1914): 0: 1103: 86.72		CBX1_MOUSE (36-180): 1.02e-53: 170: 71.33
+	Hs
		983755 ZNF91_HUMAN (979-1809): 0: 653: 12.74		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		67424 ZN850_HUMAN (321-1032): 0: 625: 12.67		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		1027143 ZN420_HUMAN (1321-1809): 4.24e-107: 360: 11.74		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		1027201 ZN570_HUMAN (516-881): 1.56e-88: 301: 17.05		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		800406 Z585B_HUMAN (322-736): 1.99e-89: 311: 11.59		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		800425 Z585A_HUMAN (322-736): 3.71e-89: 311: 11.36		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		1027274 ZN287_HUMAN (1320-1648): 5.21e-74: 265: 13.10		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		200243 ZN264_HUMAN (553-890): 3.4e-88: 304: 16.71		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		728565 ZNF93_HUMAN (323-661): 6.81e-74: 261: 10.24		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		1027128 ZN565_HUMAN (532-797): 4.12e-72: 254: 19.12		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		1027294 ZN226_HUMAN (321-641): 6.89e-65: 239: 10.06		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		316196 ZN107_HUMAN (1279-1813): 3.76e-101: 346: 12.34		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78
+	Hs
		1027309 ZN629_HUMAN (1392-1641): 3.41e-63: 235: 12.08		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		800447 ZN227_HUMAN (469-740): 6.87e-62: 230: 15.65		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		316192 ZN629_HUMAN (1392-1641): 3.41e-63: 235: 12.08		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78