HitPredict

Interactor 1: AAPK1 (Q13131)
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
Gene: PRKAA1

Interactor 2: UBP10 (Q14694)
Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)
Gene: USP10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	26876938, 30056112
Identification Methods	enzymatic study, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006914 - autophagy
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 559 Hs			1 798
+	Hs
		871383 AAPK2_HUMAN (13-559): 0: 535: 75.41		UBP10_HUMAN (1-798): 0: 720: 100.00
+	Hs
		271084 AAPK1_HUMAN (1-559): 0: 595: 100.00		UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82
+	Hs
		1183143 MARK2_HUMAN (10-545): 5.04e-150: 451: 29.64		UBP21_HUMAN (200-793): 7.22e-100: 322: 16.69
+	Hs
		1183139 MARK2_HUMAN (10-545): 5.04e-150: 451: 29.64		UBP36_HUMAN (369-795): 4.36e-90: 309: 22.94
+	Hs
		647975 MARK3_HUMAN (3-543): 7.31e-144: 434: 28.21		UBP21_HUMAN (200-793): 7.22e-100: 322: 16.69
+	Hs
		1296789 MARK4_HUMAN (18-543): 9.01e-140: 424: 28.76		UBP21_HUMAN (200-793): 7.22e-100: 322: 16.69
+	Sc
		419924 SNF1_YEAST (23-475): 3.4e-141: 424: 38.62		UBP8_YEAST (416-797): 3.64e-85: 280: 23.66